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SARS-CoV-2相关产品

由SARS-CoV-2造成的大流行是国际关注的突发公共卫生事件,WHO数据显示,截至6月12日,全球累计确诊病例已超过738万。ACROBiosystems始终密切关注着疫情的发展态势,加快SARS-CoV-2抗原蛋白、抗体、试剂盒等相关产品的研发速度,以助力血清学检测试剂盒、治疗性抗体、疫苗的开发等。
目前,ACROBiosystems已开发SARS-CoV-2相关产品60余种,包括重组蛋白、抗体、试剂盒、磁珠等,覆盖SARS-CoV-2重要靶点。ACROBiosystems已为多家体外诊断公司提供核心蛋白、抗体原料,支持SARS-CoV-2诊断试剂盒的研发。
抗体
自开发出人源中和抗体后,ACROBiosystems又隆重推出配对S1/N抗体,具有0.01nM级超高亲和力,检测灵敏度高达12 pg/mL,可用于抗原检测诊断试剂盒开发。
配对抗体
  1. 应用于抗原检测诊断试剂盒开发
  2. > 12 pg/mL高检测灵敏度 (ELISA assay)
  3. > 0.01 nM级超高亲和力 (BLI assay)
  4. > 批间差异小,可大量供货
中和抗体
  1. 可作为对照品应用于中和抗体滴度检测、假病毒中和实验等
  2. > 中和活性强,特异性高
  3. > 分离自康复患者血清
  4. > 基因工程抗体,哺乳动物细胞重组表达,批间差异小
人源抗体
  1. 可作为对照品应用于抗体滴度检测、免疫印迹实验等
  2. > 特异性高
  3. > 分离自康复患者血清
  4. > 基因工程抗体,哺乳动物细胞重组表达,批间差异小
验证数据
ELISA验证配对N抗体对抗原的检测灵敏度为 12 pg/mL

Fig 1 Immobilized Anti- SARS-CoV-2 Nucleocapsid antibody, mouse Mab (Cat. No. NUN-S46) at 4 μg/mL, add increasing concentrations of SARS-CoV-2 Nucleocapsid protein and then add Biotinylated Anti- SARS-CoV-2 Nucleocapsid antibody, mouse Mab (Cat. No. NUN-S47). Detection was performed using HRP-conjugated streptavidin with sensitivity of 12 pg/mL.

BLI验证N抗体与抗原结合的亲和力常数为 24.7 pM

Fig 2 Anti-SARS-CoV-2 Nucleocapsid Antibody, Mouse MAb(Cat. No. NUN-S47) can bind SARS-CoV-2 Nucleocapsid Protein(Cat. No. NUN-C5227) with an affinity constant of 24.7pM determined in BLI assay (ForteBio Octet Red96e)

产品列表
Molecule Cat. No. Species Product Description Preorder/Order
Nucleocapsid protein NUN-S41 Human Anti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1

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NUN-S42 Human Anti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1

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NUN-S46A1 Mouse Anti-SARS-CoV-2 Nucleocapsid Antibody, Mouse mAb

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NUN-S47A1 Mouse Anti-SARS-CoV-2 Nucleocapsid Antibody, Mouse mAb

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S1 protein S1N-M122 Mouse Anti-SARS-CoV-2 Spike S1 Antibody, Chimeric mAb

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S1N-M130 Mouse Anti-SARS-CoV-2 Spike S1 Antibody, Chimeric mAb

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S1 protein NTD SPD-M121 Mouse Anti-SARS-CoV-2 Spike NTD antibody, Human IgG1

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S protein RBD SAD-S35 Human Anti-SARS-CoV-2 RBD Neutralizing Antibody, Human IgG1

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SPD-M141 Mouse Anti-SARS-CoV-2 Spike RBD Antibody, Human IgM

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重组蛋白
SARS-CoV-2是一种单链RNA的β冠状病毒,包含S、E、M、N四种典型结构蛋白,通过S蛋白来附着并侵入宿主细胞,S蛋白包括S1和S2两个亚基,其中S1亚基上的RBD位点可以与人体肺部细胞表面的ACE2结合,使病毒膜与宿主细胞膜融合而完成入侵过程。因此,S蛋白是疫苗设计、治疗性抗体和诊断方法的关键靶标,而SARS-CoV-2 S、S1、S RBD、human ACE2等蛋白的质量和应用是抗病毒药物开发的关键。
ACROBiosystems基于HEK293的人源细胞表达平台开发出了近50种高质量的SARS-CoV-2相关蛋白产品,经ELISA/MALS/SPR/BLI等技术验证,确认其天然结合活性。
诊断专用蛋白
  1. > 可定制,克级供应
  2. > 纯度高,批间差异小
  3. > 胶体金和酶联免疫验证
三聚体S蛋白
  1. > 分子量和聚体形式经验证
  2. > 天然结合活性经验证
  3. > 可正确发挥生物学功能
生物素标记蛋白
  1. > 独特Avitag™技术
  2. > 标记均一,天然活性
  3. > 纯度高,批间差异小
病毒抗原蛋白
  1. > 天然构象,糖基化修饰完整
  2. > 纯度高,批间差异小
  3. > 活性经验证
相关宿主ACE2蛋白
  1. > 纯度高,批间差异小
  2. > 结合活性高
  3. > 多种属可供选择
验证数据

Fig 3. The purity of SARS-CoV-2 S protein (R683A, R685A), His Tag, Super stable trimer (Cat. No. SPN-C52H9) was more than 90% verified by SDS-PAGE under reducing (R) condition. The molecular weight was around 550-660 kDa confirmed by SEC-MALS. The particles are similar in size and appearance to SARS-CoV-2 trimers reported in published literature verified by negative stain electron micrography.

Protocol

Fig.4 Immobilized Human ACE2, Fc Tag (Cat. No. AC2-H5257) at 2 μg/mL (100 μL/well) can bind SARS-CoV-2 S protein (R683A, R685A), His Tag, Super stable trimer (Cat. No. SPN-C52H9) with a linear range of 0.5-16 ng/mL.

Protocol

产品列表
Molecule Cat. No. Species Tag Host Product Description Preorder/Order
ACE2 AC2-H52H8 Human His Tag HEK293 Human ACE2 / ACEH Protein, His Tag (MALS verified)

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AC2-H82E6 Human His Tag & Avi Tag HEK293 Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)

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AC2-H5257 Human Fc Tag HEK293 Human ACE2 / ACEH Protein, Fc Tag (MALS verified)

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AC2-H82F9 Human Fc Tag & Avi Tag HEK293 Biotinylated Human ACE2 / ACEH Protein, Fc,Avitag™

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AC2-C52H7 Cynomolgus His Tag HEK293 Cynomolgus ACE2 / ACEH Protein, His Tag

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AC2-M5248 Mouse His Tag HEK293 Mouse ACE2 / ACEH Protein, His Tag (MALS verified)

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AC2-R5246 Rat His Tag HEK293 Rat ACE2 / ACEH Protein, His Tag (MALS verified)

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AC2-P5248 Paguma larvata His Tag HEK293 Paguma larvata ACE2 / ACEH Protein, His Tag (SPR verified)

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S protein SPN-C52H9 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S protein (R683A, R685A), His Tag, Super stable trimer (MALS & NS-EM verified)

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SPN-C82E9 SARS-CoV-2 His Tag & Avi Tag HEK293 Biotinylated SARS-CoV-2 (COVID-19) S protein (R683A, R685A), His,Avitag™, Super stable trimer (MALS verified)

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SPN-C52H8 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S protein (R683A, R685A), His Tag, active trimer (MALS verified)

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SPN-S52H5 SARS His Tag HEK293 SARS S protein (R667A), His Tag

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S1 protein S1N-C52H4 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S1 protein, His Tag (MALS verified)

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S1N-C52H3 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S1 protein, His Tag

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S1N-C5256 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S1 protein (D614G), His Tag

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S1N-C82E3 SARS-CoV-2 His Tag & Avi Tag HEK293 Biotinylated SARS-CoV-2 (COVID-19) S1 protein (D614G), His,Avitag™

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S1N-C82E8 SARS-CoV-2 His Tag & Avi Tag HEK293 Biotinylated SARS-CoV-2 (COVID-19) S1 protein, His,Avitag™ (MALS verified)

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S1N-C5255 SARS-CoV-2 Fc Tag HEK293 SARS-CoV-2 (COVID-19) S1 protein, Fc Tag

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S1N-C5257 SARS-CoV-2 Mouse IgG Fc Tag HEK293 SARS-CoV-2 (COVID-19) S1 protein, Mouse IgG2a Fc Tag

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S1N-S52H5 SARS His Tag HEK293 SARS S1 protein, His Tag (MALS verified)

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SIN-V52H3 HCoV-NL63 His Tag HEK293 HCoV-NL63 S1 protein, His Tag

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SIN-V52H4 HCoV-229E His Tag HEK293 HCoV-229E S1 protein, His Tag

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S protein RBD SPD-C52H3 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S protein RBD, His Tag (MALS verified)

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SPD-C82E9 SARS-CoV-2 His Tag & Avi Tag HEK293 Biotinylated SARS-CoV-2 (COVID-19) S protein RBD, His,Avitag™ (MALS verified)

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SPD-S52H4 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S protein RBD (V367F), His Tag

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SPD-S52H5 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S protein RBD (N354D), His Tag

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SPD-S52H7 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S protein RBD (W436R), His Tag

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SPD-S52H8 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S protein RBD (R408I), His Tag

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SPD-S52H3 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S protein RBD (N354D, D364Y), His Tag

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SPD-C52H4 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S protein RBD (G476S), His Tag

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SPD-C52H5 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S protein RBD (V483A), His Tag

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SPD-C5255 SARS-CoV-2 Fc Tag HEK293 SARS-CoV-2 (COVID-19) S protein RBD, Fc Tag (MALS verified)

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SPD-C5259 SARS-CoV-2 Mouse IgG Fc Tag HEK293 SARS-CoV-2 (COVID-19) S protein RBD, Mouse IgG2a Fc Tag(MALS verified)

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SPD-C82Aa SARS-CoV-2 Mouse IgG Fc Tag & Avi Tag HEK293 Biotinylated SARS-CoV-2 (COVID-19) S protein RBD, Mouse IgG1 Fc,Avitag™(MALS verified)

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SPD-S52H6 SARS His Tag HEK293 SARS S protein RBD, His Tag (MALS verified)

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S1 protein NTD S1D-C52H6 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S1 protein NTD, His Tag

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S1 protein CTD S1D-C52H3 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S1 protein CTD, His Tag (MALS-verified)

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S2 protein S2N-C52H5 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) S2 protein, His Tag

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Nucleocapsid protein NUN-C5227 SARS-CoV-2 His Tag HEK293 SARS-CoV-2 (COVID-19) Nucleocapsid protein, His Tag

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NUN-C51H9 SARS-CoV-2 His Tag E.coli SARS-CoV-2 (COVID-19) Nucleocapsid protein, His Tag

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NUN-C81Q6 SARS-CoV-2 His Tag & Avi Tag E.coli Biotinylated SARS-CoV-2 (COVID-19) Nucleocapsid protein, His,Avitag™

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NUN-S5229 SARS His Tag HEK293 SARS Nucleocapsid protein, His Tag

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Envelope protein ENN-C5128 SARS-CoV-2 His Tag & GST Tag E.coli SARS-CoV-2 (COVID-19) Envelope protein, GST,His Tag

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Papain-like Protease PAE-C5148 SARS-CoV-2 His Tag E.coli SARS-CoV-2 (COVID-19) Papain-like Protease Protein, His Tag

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RNA-dependent RNA polymerase RNE-C55Ha SARS-CoV-2 His Tag InsectCells SARS-CoV-2 (COVID-19) RNA-dependent RNA polymerase Protein, His Tag

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NSP1 NS1-C51H7 SARS-CoV-2 His Tag E.coli SARS-CoV-2 (COVID-19) NSP1 Protein, His Tag

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NSP7 NS7-C51H6 SARS-CoV-2 His Tag E.coli SARS-CoV-2 (COVID-19) NSP7 Protein, His Tag (MALS verified)

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NSP8 NS8-C5149 SARS-CoV-2 His Tag E.coli SARS-CoV-2 (COVID-19) NSP8 Protein, His Tag

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NSP7 & NSP8 NS8-C5125 SARS-CoV-2 His Tag E.coli SARS-CoV-2 (COVID-19) NSP7&NSP8 Protein, His Tag

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NSP16 & NSP10 NS0-C51W3 SARS-CoV-2 His Tag & Strep Tag E.coli SARS-CoV-2 (COVID-19) NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag

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S protein RBD SPD-M52H6 MERS His Tag HEK293 MERS S protein RBD, His Tag

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S1 protein SIN-V52H5 HCoV-OC43 His Tag HEK293 HCoV-OC43 S1 protein, His Tag

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SIN-V52H6 HCoV-HKU1(isolate N5) His Tag HEK293 HCoV-HKU1(isolate N5) S1 protein, His Tag

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Nucleocapsid protein NUN-V52H3 HCoV-OC43 His Tag HEK293 HCoV-OC43 Nucleocapsid protein, His Tag

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NUN-V52H4 HCoV-HKU1(isolate N5) His Tag HEK293 HCoV-HKU1(isolate N5) Nucleocapsid protein, His Tag

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NUN-V52H6 HCoV-NL63 His Tag HEK293 HCoV-NL63 Nucleocapsid protein, His Tag

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NUN-V52H8 HCoV-229E His Tag HEK293 HCoV-229E Nucleocapsid protein, His Tag

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NUN-M52H5 MERS His Tag HEK293 MERS Nucleocapsid protein, His Tag

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试剂盒
ACRO基于自主研发的优质SARS-CoV-2重组抗原蛋白开发了一系列试剂盒类产品,包括抑制剂筛选试剂盒、抗体滴度检测试剂盒、抗原检测试剂盒、抗原预包被酶标板等,可用于抑制剂筛选、中和抗体筛选、抗体滴度检测、抗原检测等,能够提升SARS-CoV-2治疗药物和疫苗的开发效率。
抑制剂筛选试剂盒
  1. > 可用于高效筛选SARS-CoV-2小分子和多肽抑制剂、以及中和抗体
  2. > 可同时筛选96种或480种候选抑制剂
抗体滴度检测试剂盒
  1. > 特异性好,灵敏度高,重现性好
  2. > 可应用于抗体检测、药物筛选、疫苗研发等领域
  3. > 不同抗原蛋白包被,满足不同应用需求
抗原检测试剂盒
  1. > 利用双抗体夹心法检测SARS-CoV-2抗原蛋白,灵敏度高,可通过检测抗原蛋白确定病毒感染情况、指导进行疫苗开发设计。
抗原预包被酶标板
  1. > 灵敏度高、重现性好、可自动化高通量
  2. > 适用于中和抗体筛选、生物淘选、ELISA检测等场景,有助于提高病毒治疗药物、疫苗研发的效率。
验证数据

Fig.5 Inhibition of Human ACE2 [Biotinylated]: SARS-CoV-2 S protein RBD Binding by SARS-CoV-2 inhibitor.

Serial dilutions of SARS-CoV-2 inhibitor (Cat. No. AC2-NA005) (1:2 serial dilutions, from 20 μg/mL to 0.039 μg/mL (180 nM to 0.35 nM)) was added into Biotinylated ACE2: SARS-CoV-2 S protein RBD binding reactions. The assay was performed according to the above described protocol. Background was subtracted from data points prior to log transformation and curve fitting.

Protocol

产品列表
Molecule Cat. No. Species Product Description Preorder/Order
S protein RBD EP-105 SARS-CoV-2 SARS-CoV-2 Inhibitor Screening Kit

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S1 protein TAS-K001 SARS-CoV-2 Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Spike protein S1)

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S protein RBD TAS-K002 SARS-CoV-2 Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Spike protein RBD)

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S protein RBD TAS-K003 SARS-CoV-2 Anti-SARS-CoV-2 Neutralizing Antibody Titer Serologic Assay kit

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S protein TAS-K007 SARS-CoV-2 Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (S protein trimer)

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Nucleocapsid Protein TAS-K008 SARS-CoV-2 Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Nucleocapsid Protein)

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S protein RBD TAS-K009 SARS-CoV-2 Total of Anti-SARS-CoV-2 Antibody Titer Serologic Assay kit

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Nucleocapsid Protein TAS-K010 SARS-CoV-2 SARS-CoV-2 Nucleocapsid Protein Titer Assay Kit

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S protein TAS-K011 SARS-CoV-2 SARS-CoV-2 Spike Protein Titer Assay Kit

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S1 protein TAS-K012 SARS-CoV-2 Anti-SARS-CoV-2 Antibody IgM Serologic Assay kit (S1 protein)

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S protein RBD TAS-K013 SARS-CoV-2 Anti-SARS-CoV-2 Antibody IgM Serologic Assay kit (Spike RBD protein)

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S1 protein SP-12 SARS-CoV-2 SARS-CoV-2 Spike S1 protein-Coated Plates, Clear, 96-Well

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S protein RBD RP-13 SARS-CoV-2 SARS-CoV-2 Spike protein RBD-Coated Plates, Clear, 96-Well

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预偶联蛋白磁珠
ACRO开发了高质量的S1蛋白和RBD蛋白预偶联磁珠,具有高稳定性、高捕获效率、低非特异性结合的特点,无需活化,即开即用、便捷高效,能够显著提高新冠中和抗体筛选效率。
验证数据

Fig.6 RBD pre-coupled beads binding with Anti-SARS-CoV-2 S1 antibody

0.1 mg of Beads (1mg/mL, 100 L) was washed for three times and supernatant was removed. Antibodies of the corresponding concentration of 100 L (10 g/mL~0.039 g/mL) were added. One hour later,fluorescent labeled secondary antibody was added for another one-hour-reaction, the corresponding Binding signal was detected and the Binding curve as obtained.

>>> 点击了解更多预偶联蛋白磁珠产品

产品列表
Molecule Cat. No. Species Product Description Preorder/Order
S1 protein MBS-K001 SARS-CoV-2 SARS-CoV-2 Spike S1 protein-coupled magnetic beads

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S protein RBD MBS-K002 SARS-CoV-2 SARS-CoV-2 Spike protein RBD-coupled magnetic beads

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ACE2 MBS-K013 SARS-CoV-2 Human ACE2-coupled magnetic beads

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S protein RBD MBS-K014 SARS-CoV-2 Anti-SARS-CoV-2 Spike RBD Antibody-coupled magnetic beads

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更多SARS-CoV-2系列产品

>>> SARS-CoV-2诊断专用蛋白产品

>>> SARS-CoV-2试剂盒类产品

>>> 预偶联蛋白磁珠产品

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