搜索
>产品 > SARS-CoV-2抑制剂筛选试剂盒

SARS-CoV-2试剂盒类产品

背景
SARS-CoV-2通过表面刺突蛋白(S protein)来附着并侵入宿主细胞,S蛋白包括S1和S2两个亚基,其中S1亚基上的受体结合结构域(RBD)可以与人体部分肺部细胞表面的血管紧张素转换酶2(ACE2)结合,促进病毒包膜与宿主细胞膜融合而完成入侵过程。因此,S蛋白、S1蛋白、RBD蛋白是开发SARS-CoV-2治疗药物的重要靶点。
优质的病毒重组蛋白及以重组蛋白为基础开发的试剂盒产品在加速开发针对SARS-CoV-2的药物和疫苗过程中起到至关重要的作用。ACROBiosystems基于自主研发的优质SARS-CoV-2重组抗原蛋白开发了一系列试剂盒类产品,包括抑制剂筛选试剂盒、抗体滴度检测试剂盒、抗原检测试剂盒、抗原预包被酶标板等,可用于抑制剂筛选、中和抗体筛选、抗体滴度检测、抗原检测等,能够提升SARS-CoV-2治疗药物和疫苗的开发效率。
产品类型
抑制剂筛选试剂盒

SARS-CoV-2抑制剂筛选试剂盒可用于高效筛选SARS-CoV-2小分子和多肽抑制剂、以及中和抗体,能够帮助客户快速筛选和验证药物,可以有效提高研发效率。

特点
高特异性
  1. > 采用生物素标记ACE2蛋白,特异性高
高重现性
  1. > 试剂盒经过严格质控,批间差异小
高通用性
  1. > 可用于筛选更多种属的抗体与小分子化合物抑制剂
方便快捷
  1. > 操作简单快捷,提高筛选效率
高通量
  1. > 96tests和480tests两种包装规格,可高通量、快速地筛选抑制剂
验证数据

Fig.1 Inhibition of Human ACE2 [Biotinylated]: SARS-CoV-2 S protein RBD Binding by SARS-CoV-2 inhibitor.

Serial dilutions of SARS-CoV-2 inhibitor (Cat. No. AC2-NA005) (1:2 serial dilutions, from 20 μg/mL to 0.039 μg/mL (180 nM to 0.35 nM)) was added into Biotinylated ACE2: SARS-CoV-2 S protein RBD binding reactions. The assay was performed according to the above described protocol. Background was subtracted from data points prior to log transformation and curve fitting.

* 该试剂盒可提供配套Buffer套装(Cat.No. EBS-001 ELISA Buffer Set-96T)

抗体滴度检测试剂盒

ACROBiosystems开发了一系列抗体滴度检测试剂盒,包括IgG抗体滴度检测试剂盒、IgM抗体滴度试剂盒、总抗体滴度检测试剂盒、总保护性中和抗体滴度检测试剂盒等。该系列抗体滴度检测试剂盒可应用于疫苗研发领域,通过检测抗体含量验证疫苗的有效性,还可用于评估感染病人体内抗体滴度的科学研究。中和抗体的滴度检测结果体现其病毒中和能力,可作为筛选药物的依据之一。

特点
性能优异
  1. > 基于自主研发的优质蛋白开发,特异性好,灵敏度高,重现性好
品类齐全
  1. > 不同抗原蛋白包被,满足不同应用需求
验证数据

Fig.2 Detection of Monoclonal Anti-SARS-CoV-2 Antibody, Human IgG1 titer by Indirect-ELISA Assay

Immobilized SARS-CoV-2 S protein RBD at 0.2 μg/mL (100 μL/well) can bind Monoclonal Anti-SARS-CoV-2 Antibody, Human IgG1 in 1:50 human serum.Detection was performed using HRP-Conjugated Anti-human IgG antibody with sensitivity of 24 ng/mL.

Fig.3 Determination of Anti-SARS-CoV-2 Neutralizing Antibody titer in different concentrations of human serum.

Neutralizing titer of Anti-SARS-CoV-2 Neutralizing Antibody, Human IgG1 (Cat.No.SAD-S35) measured by Anti-SARS-CoV-2 neutralizing antibody titer serologic assay kit (Cat. No. TAS-K003) in different concentrations of human serum (CV < 30%).

抗原检测试剂盒

利用双抗体夹心法检测SARS-CoV-2抗原蛋白,灵敏度高,可通过检测抗原蛋白确定病毒感染情况、指导进行疫苗开发设计。ACROBiosystems研发了SARS-CoV-2 S1抗原蛋白和N抗原蛋白检测试剂盒,灵敏度高、特异性好。

验证数据

Fig.4 Detection SARS-CoV-2 Nucleocapsid Protein by ELISA Assay.

Immobilized Anti-SARS-CoV-2 Nucleocapsid Antibody at 4 μg/mL (100 μL/well) can bind SARS-CoV-2 Nucleocapsid Protein. And then add Biotinylated Anti-SARS-CoV-2 Nucleocapsid Antibody at 1:5000. Detection was performed using high sensitivity HRP-conjugated streptavidin with sensitivity of 12.5 pg/mL.

抗原预包被酶标板

预包被S1蛋白和RBD蛋白的酶标板,可用于快速定量抗SARS-CoV-2抗体或ACE2蛋白。该系列产品灵敏度高、重现性好、可自动化高通量,适用于中和抗体筛选、生物淘选、ELISA检测等场景,有助于提高病毒治疗药物、疫苗研发的效率。

验证数据

Fig.5 Binding with Anti-SARS-CoV-2 S1 antibody

Immobilized biotinylated SARS-CoV2 Spike protein RBD at 1 μg/mL (100 μL/well) on Streptavidin Coated Plates, Clear, 96-Well (Cat. No. SP-11), can bind anti-SARS-CoV-2 S1 antibody with a linear range of 0.1-2 ng/mL

产品列表
类别 分子 货号 产品描述
中和抗体滴度检测试剂盒 S protein RBD TAS-K003 Anti-SARS-CoV-2 neutralizing antibody titer serologic assay kit
抗体滴度检测试剂盒 S1 protein TAS-K001 Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (S protein S1)
S protein RBD TAS-K002 Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (S protein RBD)
S protein TAS-K007 Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (S protein trimer)
Nucleocapsid Protein TAS-K008 Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Nucleocapsid Protein)
S protein RBD TAS-K009 Anti-SARS-CoV-2 Total Antibody Titer Serologic Assay kit
S1 protein TAS-K012 Anti-SARS-CoV-2 Antibody IgM Serologic Assay kit (S1 protein)
S protein RBD TAS-K013 Anti-SARS-CoV-2 Antibody IgM Serologic Assay kit (Spike RBD protein)
抗体亚型检测试剂盒 S protein RBD TAS-K014 Anti-SARS-CoV-2 IgG1 Titer Serologic Assay Kit (S Protein RBD)
S protein RBD TAS-K015 Anti-SARS-CoV-2 IgG2 Titer Serologic Assay Kit (S Protein RBD)
S protein RBD TAS-K016 Anti-SARS-CoV-2 IgG3 Titer Serologic Assay Kit (S Protein RBD)
S protein RBD TAS-K017 Anti-SARS-CoV-2 IgG4 Titer Serologic Assay Kit (S Protein RBD)
抗原检测试剂盒 Nucleocapsid Protein TAS-K010 SARS-CoV-2 Nucleocapsid Protein Titer Assay Kit
S protein TAS-K011 SARS-CoV-2 Spike Protein Titer Assay Kit
抑制剂筛选试剂盒 S protein RBD EP-105 SARS-CoV-2 Inhibitor Screening Kit
抗原预包被酶标板 S1 protein SP-12 SARS-CoV-2 Spike S1 protein-Coated Plates, Clear, 96-Well
S protein RBD RP-13 SARS-CoV-2 Spike protein RBD-Coated Plates, Clear, 96-Well

>>> 如果您有更多需求及建议,请 点击查看

>>> 点击查看全部SARS-CoV-2蛋白和试剂盒产品

消息提示

请输入您的联系方式,再点击提交!

确定