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诊断抗原抗体原料——致力于更高的灵敏度和特异性

背景
目前,SARS-CoV-2的诊断方法主要有三种:核酸检测、抗体检测、抗原检测。其中,抗体检测和抗原检测更加简便快捷,更适合快速筛查和即时检测场合。灵敏度和特异性是衡量诊断试剂盒质量的关键指标,相应的抗原、抗体原料的质量对试剂盒的灵敏度和特异性具有重要影响。
ACROBiosystems致力于支持更高灵敏度和特异性诊断试剂盒的开发,已为多家体外诊断公司提供高质量核心抗原、抗体原料,其中美国诊断公司Babson Diagnostics以ACRO特色的生物素标记S1蛋白为原料开发的抗体检测试剂盒已获得美国FDA的紧急使用授权。
配对抗体

针对抗原检测诊断试剂盒开发优化设计的配对抗体,具有0.01nM级超高亲和力,检测灵敏度高达12 pg/mL,适用于胶体金、酶联免疫、化学发光法等平台。

产品列表
Category Cat. No. Host Product Description
Nucleocapsid protein Antibody Pair NUN-S41A1 Human Anti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1 (recommended as capture antibody when applied for ELISA) 点击咨询
NUN-S42A1 Human Anti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1 (recommended as detection antibody when applied for ELISA) 点击咨询
Nucleocapsid protein Antibody Pair NUN-S46 Mouse Anti-SARS-CoV-2 Nucleocapsid Antibody, Mouse mAb (recommended as capture antibody when applied for ELISA) 点击咨询
NUN-S47 Mouse Anti-SARS-CoV-2 Nucleocapsid Antibody, Mouse mAb (recommended as detection antibody when applied for ELISA) 点击咨询
S1 protein Antibody Pair S1N-M12A1 Mouse Anti-SARS-CoV-2 Spike S1 Antibody, Chimeric mAb (recommended as capture antibody when applied for ELISA) 点击咨询
S1N-M13A1 Mouse Anti-SARS-CoV-2 Spike S1 Antibody, Chimeric mAb (recommended as detection antibody when applied for ELISA) 点击咨询

>>> 如果您对以上产品有克级需求,请点击咨询

验证数据
ELISA验证配对N抗体对抗原的检测灵敏度为 12 pg/mL

Fig 1 Immobilized Anti- SARS-CoV-2 Nucleocapsid antibody, mouse Mab (Cat. No. NUN-S46) at 4 μg/mL, add increasing concentrations of SARS-CoV-2 Nucleocapsid protein and then add Biotinylated Anti- SARS-CoV-2 Nucleocapsid antibody, mouse Mab (Cat. No. NUN-S47). Detection was performed using HRP-conjugated streptavidin with sensitivity of 12 pg/mL.

Protocol

BLI验证N抗体与抗原结合的亲和力常数为 24.7 pM

Fig 2 Anti-SARS-CoV-2 Nucleocapsid Antibody, Mouse MAb(Cat. No. NUN-S47) can bind SARS-CoV-2 Nucleocapsid Protein(Cat. No. NUN-C5227) with an affinity constant of 24.7pM determined in BLI assay (ForteBio Octet Red96e)

Protocol

N抗体可特异性结合SARS-CoV-2 N抗原

Fig 3 Demonstration of the specificity of Anti-SARS-CoV-2 N antibody (Cat. No. NUN-S42) to the Nucleocapsid protein.

批间差异小

Fig 4 Demonstration of the Batch to Batch Consistency of Anti-SARS-CoV-2 Spike S1 Antibody, Chimeric Mab (Cat. No. S1N-M122) to the S1 protein.

抗原

专门针对抗体检测试剂盒开发优化设计的S、N抗原,现货供应,可根据需求提供定制化服务,适用于胶体金、酶联免疫、化学发光法等平台。

产品列表
Category Cat. No. Host Product Description
S protein SPN-C52H2 HEK293 SARS-CoV-2 (COVID-19) S protein (R683A, R685A) , His Tag, active trimer (MALS verified) 点击咨询
S1 protien S1N-C52H2 HEK293 SARS-CoV-2 (COVID-19) S1 protein, His Tag (MALS verified) 点击咨询
S1N-C82E8 HEK293 Biotinylated SARS-CoV-2 (COVID-19) S1 protein, His,Avitag™ (MALS verified) 点击咨询
S2 protein S2N-C52H2 HEK293 SARS-CoV-2 (COVID-19) S2 protein, His Tag 点击咨询
RBD protein SPD-C52H1 HEK293 SARS-CoV-2 (COVID-19) S protein RBD, His Tag (MALS verified)* 点击咨询
SPD-C52H2 HEK293 SARS-CoV-2 (COVID-19) S protein RBD, His Tag (MALS verified)* 点击咨询
SPD-C5251 HEK293 SARS-CoV-2 (COVID-19) S protein RBD, Mouse IgG2a Fc Tag 点击咨询
SPD-C82E9 HEK293 Biotinylated SARS-CoV-2 (COVID-19) S protein RBD, His,Avitag™ (MALS verified) 点击咨询
Nucleocapsid protein NUN-C5221 HEK293 SARS-CoV-2 (COVID-19) Nucleocapsid protein, His Tag 点击咨询
NUN-C51H2 E.coli SARS-CoV-2 (COVID-19) Nucleocapsid protein, His Tag 点击咨询
NUN-C81Q8 E.coli Biotinylated SARS-CoV-2 (COVID-19) Nucleocapsid protein, His,Avitag™ 点击咨询
Envelope Protein ENN-C5128 HEK293 SARS-CoV-2 (COVID-19) Envelope protein, GST,His Tag 点击咨询

*SARS-CoV-2 (COVID-19) S protein RBD, His Tag (MALS verified) (货号:SPD-C52H1, SPD-C52H2)为不同表达区间RBD蛋白产品。

>>> 如果您对以上产品有克级需求,请点击咨询

>>> 如果您有定制化的产品、服务需求,请点击提议

验证数据
经ELISA验证,N蛋白结合抗单克隆抗体的灵敏度为0.02 ng/mL
Fig.5 Immobilized SARS-CoV-2 Nucleocapsid protein, His Tag at 2 μg/mL (100 μL/well) can bind SARS-CoV-2 NP Antibody, Rabbit MAb (CLN27) with a linear range of 0.02-0.3 ng/mL.

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