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ActiveMax® Recombinant Human IL-6

分子别名(Synonym)

IL6,HGF,Interleukin-6,BSF2,HSF,IFNB2

表达区间及表达系统(Source)

Human IL-6, Tag Free (IL6-H4218) is expressed from human 293 cells (HEK293). It contains AA Val 30 - Met 212 (Accession # NP_000591).

Predicted N-terminus: Val 30

蛋白结构(Molecular Characterization)

Online(Val 30 - Met 212) NP_000591

This protein carries no "tag".

The protein has a calculated MW of 20.8 kDa. The protein migrates as 23-25 kDa and 26-30 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>98% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human IL-6, Tag Free (Cat. No. IL6-H4218) SDS-PAGE gel

Human IL-6, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 98%.

 

活性(Bioactivity)-ELISA

Biotinylated Human ELISA

Immobilized Human IL-6, Tag Free (Cat. No. IL6-H4218) at 5 μg/mL (100 μL/well) can bind Biotinylated Human IL-6 R alpha, His Tag (Cat. No. CD6-H82E8) with a linear range of 4-125 ng/mL (QC tested).

点击申请Protocol

 

文献引用(Citations)

背景(Background)

Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.

 

前沿进展

货号/价格

IL6-H4218-20ug / ¥1600

IL6-H4218-50ug / ¥3500

产品定制
文档
联系电话:
400-682-2521(全国)
010-57737274(北京)
021-31604788(上海)
订单邮箱:
order.cn@acrobiosystems.com
技术支持邮箱:
techsupport@acrobiosystems.com
IL-6靶点信息
英文全称:Interleukin-6
中文全称:白细胞介素-6
种类:Homo sapiens
上市药物数量:2详情
临床药物数量:21详情
最高研发阶段:批准上市
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