搜索
 >  其他蛋白>LRP-5 >Human LRP-5 (32-643) Protein, Mouse IgG2a Fc Tag

Human LRP-5 (32-643) Protein, Mouse IgG2a Fc Tag

此产品为在研产品。如果您对此产品有兴趣,请直接联系我们。我们会根据您的需求相应地加速我们的研发进程,并为您进行产品预留。

分子别名(Synonym)

LRP-5,LRP-5,LRP-7,LRP7,LR3

表达区间及表达系统(Source)

Human LRP-5 (32-643), Mouse IgG2a Fc Tag (LR5-H5258) is expressed from human 293 cells (HEK293). It contains AA Ser 32 - Pro 643 (Accession # O75197-1 ).

Predicted N-terminus: Ser 32

蛋白结构(Molecular Characterization)

Online-Res(Ser 32 - Pro 643) O75197-1 

This protein carries a mouse IgG2a Fc tag at the C-terminus.

The protein has a calculated MW of 95.6 kDa.

内毒素(Endotoxin)

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, Arginine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

背景(Background)

Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.

 

前沿进展

货号/价格

LR5-H5258-100ug / ¥3500

LR5-H5258-1mg / ¥23100

开发建议
文档
联系电话:
400-682-2521(全国)
010-57737274(北京)
021-26136428(上海)
订单邮箱:
order.cn@acrobiosystems.com
技术支持邮箱:
techsupport@acrobiosystems.com

消息提示

请输入您的联系方式,再点击提交!

确定