搜索
 >  其他蛋白>FOLR2 >FO2-C52H4

Cynomolgus FOLR2 Protein, His Tag

此产品为在研产品。如果您对此产品有兴趣,请直接联系我们。我们会根据您的需求相应地加速我们的研发进程,并为您进行产品预留。

分子别名(Synonym)

FOLR2,BETA-HFR,FBP/PL-1,FR-BETA,FR-P3,FBP

表达区间及表达系统(Source)

Cynomolgus FOLR2, His Tag (FO2-C52H4) is expressed from human 293 cells (HEK293). It contains AA Val 47 - Gln 222 (Accession # A0A2K5U027-1).

Predicted N-terminus: Val 47

蛋白结构(Molecular Characterization)

Online-Res(Val 47 - Gln 222) A0A2K5U027-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 22.4 kDa.

内毒素(Endotoxin)

制剂(Formulation)

Please contact us for detailed information.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

背景(Background)

Folate receptor beta is also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family. and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.

 

前沿进展

货号/价格

FO2-C52H4-100ug / ¥3000

FO2-C52H4-1mg / ¥19800

开发建议 点击预购
文档
联系电话:
400-682-2521(全国)
010-57737274(北京)
021-26136428(上海)
运输方式
订单邮箱:
order.cn@acrobiosystems.com
技术支持邮箱:
techsupport@acrobiosystems.com
FOLR2靶点信息
英文全称:Folate receptor beta
中文全称:叶酸受体β
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:6详情
最高研发阶段:临床三期
查看更多信息

消息提示

请输入您的联系方式,再点击提交!

确定