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Human Coagulation Factor III / Tissue Factor Protein, Fc Tag

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分子别名(Synonym)

Coagulation Factor III,Tissue Factor,TF,F3,CD142

表达区间及表达系统(Source)

Human Tissue Factor, Fc Tag (TF3-H5253) is expressed from human 293 cells (HEK293). It contains AA Ser 33 - Glu 251 (Accession # P13726-1).

Predicted N-terminus: Ser 33

蛋白结构(Molecular Characterization)

Online-Res(Ser 33 - Glu 251) P13726-1

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 50.7 kDa.

内毒素(Endotoxin)

制剂(Formulation)

Please contact us for detailed information.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

背景(Background)

Full-length tissue factor (TF) is a transmembrane receptor and cofactor for factor (F)VII/FVIIa. In addition to full-length TF, an alternative spliced (as) form of TF can be generated that lacks the transmembrane domain and is released fromcells. In contrast to TF, asTF has low procoagulant activity because it lacks the transmembrane domain. Tissue factor is expressed by cells around blood vessels, such as adventitial fibroblasts, and body surfaces, such as epithelial cells, and plays a critical role in hemostasis. TF also contributes to various forms of thrombosis. Many cancers, particularly adenocarcinomas, express high levels of TF. A high level of tumor TF expression is associated with poor prognosis in many types of cancers, including breast, prostate, colorectal, and pancreatic cancer.

 

前沿进展

 
货号/价格

TF3-H5253-100ug / ¥3500

TF3-H5253-1mg / ¥23100

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