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 >  Protein>CD48 >BC1-H5226

Human CD48 / SLAMF2 Protein, His Tag (MALS verified)

分子别名(Synonym)

CD48,BCM1,SLAMF2,BLAST,BLAST1,MEM-102,TCT.1,BCM-1,SLAMF-2,BLAST-1

表达区间及表达系统(Source)

Human CD48, His Tag (BC1-H5226) is expressed from human 293 cells (HEK293). It contains AA Gln 27 - Ser 220 (Accession # AAH16182 ).

Predicted N-terminus: Gln 27

Request for sequence

蛋白结构(Molecular Characterization)

CD48 Structure

This protein carries a polyhistidine tag at the C-terminus

The protein has a calculated MW of 23.2 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

CD48 SDS-PAGE

Human CD48, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS

CD48 SEC-MALS

The purity of Human CD48, His Tag (Cat. No. BC1-H5226) is more than 90% and the molecular weight of this protein is around 32-42 kDa verified by SEC-MALS.

Report

 

活性(Bioactivity)-ELISA

CD48 ELISA

Immobilized Human CD48, His Tag (Cat. No. BC1-H5226) at 10 μg/mL (100 μL/well) can bind Human 2B4, Fc Tag (Cat. No. 2B4-H5255) with a linear range of 0.039-0.625 μg/mL (QC tested).

Protocol

 

背景(Background)

CD48 antigen is also known as Signaling lymphocytic activation molecule 2, SLAM family member 2 (SLAMF2), Leukocyte antigen MEM-102, BCM1 surface antigen, B-lymphocyte activation marker BLAST-1. CD48 is a 65 kDa GPI-linked protein which belongs to the CD2 subfamily of immunoglobulin superfamily molecules. CD48 antigen contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domain. CD48 interacts with CD244 in an heterophilic manner. CD48 is ligand for CD2. CD48 might facilitate interaction between activated lymphocytes. CD48 is probably involved in regulating T-cell activation.

 

前沿进展

 
 
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CD48靶点信息
英文全称:Cluster of differentiation 48
中文全称:分化簇48
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:0详情
最高研发阶段:终止
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