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 >  Protein>LILRB2 >LI2-H5220

Human LILRB2 / CD85d / ILT4 Protein, His Tag (MALS verified)

分子别名(Synonym)

LILRB2,ILT4,LIR2,MIR10,CD85d

表达区间及表达系统(Source)

Human LILRB2, His Tag (LI2-H5220) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Val 461 (Accession # AAH36827 ).

Predicted N-terminus: Gln 22

Request for sequence

蛋白结构(Molecular Characterization)

LILRB2 Structure

This protein carries a polyhistidine tag at the C-terminus

The protein has a calculated MW of 48.6 kDa. The protein migrates as 58-67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

LILRB2 SDS-PAGE

Human LILRB2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS

LILRB2 SEC-MALS

The purity of Human LILRB2, His Tag (Cat. No. LI2-H5220) is more than 90% and the molecular weight of this protein is around 58-78 kDa verified by SEC-MALS.

Report

 

活性(Bioactivity)-ELISA

LILRB2 ELISA

Immobilized Human LILRB2, His Tag (Cat. No. LI2-H5220) at 1 μg/mL (100 μL/well) can bind Anti-LILRB2 Antibody, Human IgG1 with a linear range of 0.5-4 ng/mL (QC tested).

Protocol

 

背景(Background)

Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is also known as CD85 antigen-like family member D (CD85d), Immunoglobulin-like transcript 4 (ILT-4), Monocyte / macrophage immunoglobulin-like receptor 10 (MIR-10), which is a member of the the subfamily B class of LIR receptors. LILRB2 is receptor for class I MHC antigens. LILRB2 recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. LILRB2 competes with CD8A for binding to class I MHC antigens. LILRB2 / CD85d inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

 

前沿进展

 
 
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LILRB2靶点信息
英文全称:Leukocyte immunoglobulin-like receptor subfamily B member 2
中文全称:白细胞免疫球蛋白样受体亚家族B成员2
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:9详情
最高研发阶段:临床二期
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