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 >  Protein>EGF R >EGR-C5252

Rhesus macaque EGF R Protein, Fc Tag (MALS verified)

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分子别名(Synonym)

EGFR,ERBB,ERBB1,HER1,PIG61,mENA

表达区间及表达系统(Source)

Rhesus macaque EGF R, Fc Tag (EGR-C5252) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Ser 645 (Accession # P55245 ).

Predicted N-terminus: Leu 25

Request for sequence

蛋白结构(Molecular Characterization)

EGF R Structure

This protein carries a human IgG1 Fc tag at the C-terminus

The protein has a calculated MW of 95.3 kDa. The protein migrates as 116-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

EGF R SDS-PAGE

Rhesus macaque EGF R, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS

EGF R SEC-MALS

The purity of Rhesus macaque EGF R, Fc Tag (Cat. No. EGR-C5252) is more than 85% and the molecular weight of this protein is around 225-245 kDa verified by SEC-MALS.

Report

 

活性(Bioactivity)-ELISA

EGF R ELISA

Immobilized Human EGF, Tag Free at 10 μg/mL (100 μL/well) can bind Rhesus macaque EGF R, Fc Tag (Cat. No. EGR-C5252) with a linear range of 39-1250 ng/mL (QC tested).

Protocol

 

背景(Background)

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.

 

前沿进展

 
 
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EGF R靶点信息
英文全称:Epidermal growth factor receptor erbB1
中文全称:表皮生长因子受体erbB1
种类:Homo sapiens
上市药物数量:32详情
临床药物数量:166详情
最高研发阶段:批准上市
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