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TL1A信息

英文名称:Tumor necrosis factor superfamily member 15
中文名称:肿瘤坏死因子超家族成员15
靶点别称:VEGI192A,Vascular Endothelial Cell Growth Inhibitor,TNF Superfamily Ligand TL1A,TNFSF15,Tumor Necrosis Factor (Ligand) Superfamily, Member 15,Vascular Endothelial Growth Inhibitor-192A,VEGI,TL1A,Tumor Necrosis Factor Ligand 1B,TNLG1B,TNF Superfamily Member 15,Tumor Necrosis Factor Superfamily Member 15,TL1,TNF Ligand-Related Molecule 1,Tumor Necrosis Factor Ligand Superfamily Member 15,MGC129934,MGC129935
上市药物数量:0
临床药物数量:4
最高研发阶段:临床三期

TL1A产品列表

ACRO质量管理体系
 
评论(9)
TLA-H5243|Human TL1A / TNFSF15 Protein, His Tag (MALS verified)
  1. 159XXXXXXX5
  2. 11人赞
  3. 主要研究TL1A抗体用于炎症性肠病(IBD)和哮喘相关的黏膜炎症治疗靶点的研究。阻断TL1A通路可以减少炎症反应,同时保持基线免疫完整。
  4. >
  5. 2023-05-16
TLA-H5243|Human TL1A / TNFSF15 Protein, His Tag (MALS verified)
  1. 136XXXXXXX9
  2. 2人赞
  3. 购买该蛋白用于筛选目的抗体,经过实验验证,得到很好的筛选结果。后续也支持目的抗体的活性检测,实验数据稳定,无干扰,每次实验都非常成功,一直相信ACRO的质量,售后也很棒。
  4. 2023-08-04
TLA-M5243|Mouse TL1A Protein, His Tag (HPLC-verified)
  1. 159XXXXXXX3
  2. 2人赞
  3. 我们购买该蛋白是为了测试它与我们生产的抗体的亲和力,有助于我们筛选出想要的抗体,总体结果来看,还是挺不错的,最重要的是,发货快,有时候会满足我们急需
  4. 2023-07-13
 

TL1A分子别名

TL1A, VEGI, TNFSF15

TL1A分子背景

TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory T-cells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating T-cell activation and downregulating the secretion of pro-inflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses.

TL1A临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Tulisokibart PRA-023; MK-7240; PRA023 临床三期 Prometheus Biosciences Inc, Merck Sharp & Dohme LLC 炎症性肠疾病, 间质性肺疾病, 溃疡性结肠炎, 弥漫性硬皮病, 克罗恩病 详情
RVT-3101 PF-06480605; PF 6480605; RVT-3101 临床二期 辉瑞 炎症性肠疾病, 溃疡性结肠炎, 克罗恩病 详情
TEV-48574 TEV-48574 临床二期 以色列梯瓦制药工业有限公司 溃疡性结肠炎, 哮喘, 克罗恩病 详情
Next-generation anti-TL1A antibody(Telavant) 临床一期 Telavant Inc 纤维化, 炎性疾病 详情

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