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Neuregulin-4信息

英文名称:Neuregulins
中文名称:神经调节蛋白类
靶点别称:Neuregulins
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

Neuregulin-4产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
NR4-H52H3
Human
Human Neuregulin-4 / NRG4 Protein, His Tag
ACRO质量管理体系
 
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Neuregulin-4 分子别名

Neuregulin-4,NRG4

Neuregulin-4 分子背景

Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene. Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival. The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation. Furthermore, NRG4 is a low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors.

Neuregulin-4 前沿进展

Neuregulin-4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
LY3461767 LY-3461767 临床一期 礼来制药 心脏衰竭 详情

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