搜索
 > 【RAGE】重组蛋白信息

RAGE信息

英文名称:Advanced glycosylation end product-specific receptor
中文名称:晚期糖基化终产物特异性受体
靶点别称:RAGE,AGER,Advanced glycosylation end product-specific receptor,Receptor for advanced glycosylation end products
上市药物数量:0
临床药物数量:6
最高研发阶段:临床三期

RAGE产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
AGR-H5253
Human
Recombinant Human RAGE / AGER Protein
 
评论(0)
 

RAGE 分子别名

AGER,RAGE

RAGE 分子背景

Advanced glycosylation end product-specific receptor (AGER) is also known as RAGE, and is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. AGER is highly expressed in endothelial cells. AGER mediates interactions of advanced glycosylation end products (AGE), and also accumulates in vascular tissue in aging and at an accelerated rate in diabetes, as well as acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGER / RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.

RAGE 参考文献

RAGE临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Azeliragon TTP-488; PF-04494700; PF-4494700,PF04494700,TTP488 临床三期 vTv Therapeutics 阿尔茨海默病 详情
Tenilsetam CAS-997 临床阶段不明 赛诺菲 痴呆
TRC-041266 TRC-041266 临床一期 Torrent Pharmaceuticals 不明
TRC-4186 TX-41XX; TRC-4186 临床二期 Torrent Pharmaceuticals 糖尿病并发症, 心力衰竭
Alagebrium chloride ALT-711 临床三期 Synvista Therapeutics 心血管疾病, 勃起功能障碍, 高血压, 心力衰竭 详情
TTP-4000 TTP-4000 临床一期 vTv Therapeutics 阿尔茨海默病 详情

消息提示

请输入您的联系方式,再点击提交!

确定