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GM-CSF信息

英文名称:Macrophage colony stimulating factor 2
中文名称:巨噬细胞集落刺激因子2
靶点别称:Molgramostin,CSF2,GM-CSF,GMCSF,Granulocyte-macrophage colony-stimulating factor,Colony-stimulating factor,CSF,Sargramostim
上市药物数量:0
临床药物数量:5
最高研发阶段:临床二期

GM-CSF产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
GMF-H8214
Human
Recombinant Human GM-CSF / CSF2 Protein, Biotinylated
GMF-H4214
Human
Recombinant Human GM-CSF / CSF2 Protein

GM-CSF 分子别名

GM-CSF,CSF2,MGC131935

GM-CSF 分子背景

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is also known as Colony stimulating factor 2 (granulocyte-macrophage), is a cytokine initially characterized by its ability to induce colonies of granulocytes and macrophages from myeloid progenitor cells, and is secreted by macrophages, T cells, mast cells, endothelial cells and fibroblasts. GM-CSF is a cytokine that functions as a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Monocytes exitthe circulation and migrate into tissue, whereupon they mature into macrophages and dendritic cells. Thus, it is part of the immune/inflammatory cascade, by which activation of a small number of macrophages can rapidly lead to an increase in their numbers, a process crucial for fighting infection. The active form of the protein is found extracellularly as a homodimer. Human GM-CSF glycosylated in its mature form. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has also recently been evaluated in clinical trials for its potential as a vaccine adjuvant in HIV-infected patients. The preliminary results have been promising. GM-CSF is also used as a medication to stimulate the production of white blood cells following chemotherapy.

GM-CSF 参考文献

GM-CSF临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Namilumab MT-203 临床二期 安进, 武田 斑块状银屑病, 多发性硬化症, 类风湿性关节炎, 慢性阻塞性肺病, 哮喘 详情
Lenzilumab KB-003 临床二期 KaloBios 慢性骨髓单核细胞性白血病, 类风湿性关节炎, 哮喘 详情
MORAb-022 MORAb-022 临床一期 Morphotek 类风湿性关节炎 详情
GSK-3196165 GSK-3196165; MOR-103; 3196165; MOR-04357 临床二期 MorphoSys, 墨尔本大学, 葛兰素史克 骨关节炎, 类风湿性关节炎 详情
PBI-1402 PBI-1402 临床二期 Prometic Life Sciences, 上海艾力斯 贫血

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