Recombinant Proteins iso9001 ISO13485
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Mouse FAP Protein, His Tag

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分子别名(Synonym)

FAP,FAPalpha,SIMP,Seprase,APCE

表达区间及表达系统(Source)

Mouse FAP, His Tag (FAP-M52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 26 - Asp 761 (Accession # P97321).

Predicted N-terminus: His

蛋白结构(Molecular Characterization)

Online-Res(Leu 26 - Asp 761) P97321

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 87.2 kDa.

内毒素(Endotoxin)

制剂(Formulation)

Please contact us for detailed information.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

背景(Background)

FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

 

前沿进展

 
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FAP靶点信息
英文全称:Fibroblast activation protein alpha
中文全称:成纤维细胞激活蛋白α
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:4详情
最高研发阶段:临床二期
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