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The purity of Canine FCGRT&B2M Heterodimer Protein, His Tag&Tag Free (Cat. No. FCM-C52W8) is more than 90% and the molecular weight of this protein is around 43-60 kDa verified by SEC-MALS.
Immobilized Biotinylated Human FCGRT&B2M Heterodimer Protein, His,Avitag (Cat. No. FCM-H82W7) on SA Chip can bind Herceptin® with an affinity constant of 0.267 μM as determined in a SPR assay (Biacore 8K) (QC tested).
申请Protocol
Mouse FCGRT&B2M Heterodimer Protein, His Tag (Cat. No. FCM-M52W8) captured on NTA-Series S sensor chip can bind Herceptin with an affinity constant of 2.52 nM as determined in a SPR assay (Biacore T200) (Routinely tested).
申请Protocol
Loaded Cynomolgus / Rhesus macaque FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (Cat. No. FCM-C5284 ) on SA Biosensor via Biotin his antibody, can bind Herceptin with an affinity constant of 0.13 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
申请Protocol
Loaded Biotinylated Human FCGRT&B2M Heterodimer Protein, His,Avitag (Cat. No. FCM-H82W7) on SA Biosensor, can bind Human Serum Albumin, His Tag (Cat. No. HSA-H5220) with an affinity constant of 0.647 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
申请Protocol
The half-lives of these 3 monoclonal antibodies currently in clinical use generally correlate with the binding affinity to FcRn. The kit (Cat.No.FRT-01) has been used to detect 3 FDA approved antibody drugs of different binding affinity to FcRn, and the IC50 trends are consistent with affinity constant from SPR as well as the actual in vivo half-life published.
申请Protocol
The kit (Cat.No.FRT-01) is suitable for the detection of FcRn inhibitors. It shows that both Efgartigimod and its biosimilar, Human IgG1 Fc (C103S, M135Y, S137T, T139E, H316K, N317F) His Tag (Cat. No. IG1-H52H8) exhibit good inhibitory activity in this TR-FRET competition assay.
申请Protocol
FACS assay shows that FITC-Labeled Human IgG1 Fc (C103S, M135Y, S137T, T139E, H316K, N317F) Protein, His Tag (Cat. No. IG1-HF2H3) can bind to HEK293/Human FcRn (FCGRT & B2M) Stable Cell Line. HEK293/Human FcRn (FCGRT & B2M) Stable Cell Line (Cat. No. CHEK-ATP079) was red line, negative control HEK293 cells was grey line(QC tested).
申请Protocol1. The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat. The Journal of Clinical Inveatigation. 1972, 51:2916–27. Authors:Jones EA, Waldmann TA.
2. FcRn: the neonatal Fc receptor comes of age. Nature Reviews Immunology. 2007,7:715–725. Authors:Derry C. Roopenian, Shreeram Akilesh.
3. Howard. FcRn expression in cancer: Mechanistic basis and therapeutic opportunities. Journal of Controlled Release. 2021, 337 :248–257. Authors:Imke Rudnik-Jansen, Kenneth A.
4. Antagonism of the Neonatal Fc Receptor as an Emerging Treatment for Myasthenia Gravis. Frontiers in Immunology. 2020, 10. Authors:Karissa L. Gable, Jeffrey T. Guptill.
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