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STEAP1无胞质氧化还原酶结构域，但可通过形成同源/异源三聚体发挥功能，在85%以上的前列腺癌组织中高表达，尤其在转移性去势抵抗性前列腺癌（mCRPC）中持续高表达，是前列腺癌诊断与靶向治疗的核心靶点，同时在膀胱癌、结直肠癌、卵巢癌等多种肿瘤中也存在异常高表达。
STEAP2具备典型的金属还原酶活性，可催化Fe³⁺还原为Fe²⁺、Cu²⁺还原为Cu⁺，参与细胞铁铜代谢调控，在前列腺癌、胰腺癌、乳腺癌等肿瘤中高表达，与肿瘤细胞增殖、侵袭及代谢重编程密切相关，是潜在的肿瘤预后标志物与治疗靶点。
STEAP3主要定位于内体与溶酶体，核心功能为铁代谢调控，通过还原铁离子参与血红蛋白合成与铁稳态维持，其表达异常与铁代谢紊乱相关疾病及多种肿瘤（如肺癌、胃癌）的发生发展相关，同时在贫血等非肿瘤疾病中也具有研究价值。
基于其重要的生物学功能和在肿瘤中的关键作用，STEAP家族已成为全球药物研发的热门创新靶点。据药渡数据统计，针对 STEAP的在研管线涵盖单克隆抗体、双特异性抗体、ADC、CAR-T 等多种前沿技术类型，适应症覆盖前列腺癌、肺癌、胃癌等高发实体瘤，具备巨大临床应用潜力。这些活跃的研发态势充分印证了STEAP靶点的重要价值，是药物研发领域不可忽视的核心靶点。
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STEAP在研管线及其进展（数据来源：药渡）
Immobilized Human STEAP1 Full Length Protein, Twin-Strep,His Tag (Cat. No. ST1-H5283) at 2 μg/mL (100 μL/well) can bind Vandortuzumab biosimilar with a linear range of 4-63 ng/mL (QC tested).
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Immobilized Biotinylated Human STEAP2 Full Length Protein, Flag,Avitag (Cat. No. ST2-H85D3) at 5 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-STEAP2 Antibody with a linear range of 0.04-1.25 μg/mL (QC tested).
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Anti-STEAP (Vandortuzumab) captured on Protein A Chip can bind Human STEAP1 Full Length Protein, Twin-Strep,His Tag (Cat. No. ST1-H5283) with an affinity constant of 2.30 nM as determined in a SPR assay (in presence of DDM and CHS) (Biacore 8K) (QC tested).
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Loaded Anti-STEAP1 Antibody on Protein A Biosensor, can bind Biotinylated Human STEAP1 Full Length Protein, Avitag, Flag&His Tag (Cat. No. ST1-H82D3) with an affinity constant of 8.26 nM as determined in BLI assay (in presence of DDM and CHS) (ForteBio Octet R8) (Routinely tested).
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The mean peak Radius of Human STEAP3 Full Length Protein (ST3-H52P3) is 65-90 nm with more than 95% intensity as determined by dynamic light scattering (DLS).
The mean peak Radius of Human STEAP4 Full Length Protein (Cat. No. ST4-H52P3) is 60-80nm with more than 95% intensity as determined by dynamic light scattering (DLS).
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