选择语言
免费注册
关注公众号
微信客服

TL1A

TL1A信息

英文名称:Tumor necrosis factor superfamily member 15上市药物数量0
中文名称肿瘤坏死因子超家族成员15临床药物数量10
靶点别称VEGI192A，Vascular Endothelial Cell Growth Inhibitor，TNF Superfamily Ligand TL1A，TNFSF15，Tumor Necrosis Factor (Ligand) Superfamily， Member 15，Vascular Endothelial Growth Inhibitor-192A，VEGI，TL1A，Tumor Necrosis Factor Ligand 1B，TNLG1B，TNF Superfamily Member 15，Tumor Necrosis Factor Superfamily Member 15，TL1，TNF Ligand-Related Molecule 1，Tumor Necrosis Factor Ligand Superfamily Member 15，MGC129934，MGC129935最高研发阶段临床三期
英文名称:Tumor necrosis factor superfamily member 15
中文名称肿瘤坏死因子超家族成员15
靶点别称VEGI192A，Vascular Endothelial Cell Growth Inhibitor，TNF Superfamily Ligand TL1A，TNFSF15，Tumor Necrosis Factor (Ligand) Superfamily， Member 15，Vascular Endothelial Growth Inhibitor-192A，VEGI，TL1A，Tumor Necrosis Factor Ligand 1B，TNLG1B，TNF Superfamily Member 15，Tumor Necrosis Factor Superfamily Member 15，TL1，TNF Ligand-Related Molecule 1，Tumor Necrosis Factor Ligand Superfamily Member 15，MGC129934，MGC129935
上市药物数量0
临床药物数量10
最高研发阶段Phase 3 Clinical

TL1A产品列表

  • 属性

    Protein (13)Cell (4)Kits (2)

  • 产品库

    在线 (19)

  • 物种

    Human (12)Cynomolgus / Rhesus macaque (2)Mouse (3)Rat (1)Rabbit (1)

  • 标签

    His Tag (7)His Tag & Avi Tag (2)- (8)Fc Tag (1)Avi Tag & His Tag (1)

  • 标记

    Unconjugated (10)Biotin-labeled (3)- (6)

共 19 项数据
  • 1
  • 2

TL1A分子背景

TL1A, also known as TNFSF15, is a member of the TNF superfamily. This type II transmembrane protein forms stable homotrimers via its TNF homology domain (THD) and is expressed in immune cells, including monocytes, macrophages, dendritic cells, and T cells, as well as non-immune cells like synovial fibroblasts and endothelial cells. By binding to Death Receptor 3 (DR3), TL1A modulates proliferation, activation, apoptosis, and cytokine/chemokine production in effector cells, contributing to both innate and adaptive immune homeostasis. Dysregulated TL1A expression is implicated in autoimmune diseases such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease, making it a promising therapeutic target for conditions like ulcerative colitis and Crohn's disease.

TL1A分子别名

TL1A, VEGI, TNFSF15

产品评论

加载更多
  • 分子信息
  • 产品列表