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CD19:有效治疗B细胞淋巴瘤的热门靶点

背景
CD19是正常和恶性B淋巴细胞特异性表面蛋白,在B细胞的发育、增殖和分化以及恶性转化中发挥重要作用。因CD19在B淋巴细胞表达的特异性和恶性肿瘤表达的广泛性,使其成为一个颇具潜力的B淋巴细胞恶性肿瘤免疫治疗的分子靶点。靶向CD19的热门免疫治疗策略包括嵌合抗原受体修饰T细胞(CAR-T)、双特异性抗体、抗体-药物偶联物(ADC)、Fc优化免疫增强抗体等,均在B细胞淋巴瘤治疗方面表现出了显著的疗效。截至2020年5月7日,已上市药物有3款,处于临床研究阶段项目763项(数据来自ClinicalTrials.gov)。

为支持靶向CD19的免疫治疗药物的开发,ACROBiosystems专门设计开发了一系列适用于免疫、抗体药筛选、亲和力检测及Anti-CD19 CAR表达检测的高亲和力CD19蛋白,包括非标记、生物素标记、荧光标记等多种形式,通过Flow cytometry、SPR、ELISA等检测方法对其性能进行了全方位的分析,保证蛋白纯度和活性,助力您的药物研发进程。

ACRO更有FDA DMF备案的CD19蛋白(DMF编号:034936)支持您的IND、NDA和BLA申请,如果您使用了DMF备案CD19蛋白并需要引用DMF编号,请向ACRO提出授权申请,收到申请后,我们将向FDA提供DMF授权书。点击申请授权
产品列表
分子名 货号 产品描述
CD19 CD9-HP2H3 PE-Labeled Human CD19 (20-291) Protein, His Tag New
CD9-HF2H2 FITC-Labeled Human CD19 (20-291) Protein, His Tag DMF Filed
CD9-HF251 FITC-Labeled Human CD19 (20-291) Protein, Fc Tag DMF Filed
CD9-H8259 Biotinylated Human CD19, Fc Tag, ultra sensitivity (primary amine labeling) DMF Filed
CD9-H82F7 Biotinylated Human CD19 (20-291) Protein, Fc,Avitag™ New
CD9-H82E9 Biotinylated Human CD19 (20-291) Protein, His,Avitag™ (SPR verified) New
MBS-K005 CD19 protein-coupled magnetic beads
CD9-H5255 Human CD19 (20-278) Protein, Fc Tag
CD9-H5259 Human CD19 (20-291) Protein, Fc Tag, low endotoxin
CD9-H5258 Human CD19 (20-291) Protein, Mouse IgG2a Fc Tag
CD9-H52H2 Human CD19 (20-291) Protein, His Tag DMF Filed
CD9-H5250 Human CD19 (20-291) Protein, Llama IgG2b Fc Tag, low endotoxin
CD9-H5251 Human CD19 (20-291) Protein, Fc Tag, low endotoxin (Super affinity) DMF Filed
CD9-C5251 Cynomolgus / Rhesus macaque CD19 (20-292) Protein, Fc Tag

>>> 如果您有其他产品的FDA DMF备案需求,欢迎联系我们。点击咨询

产品特点
经流式验证适用于Anti-CD19 CAR阳性表达率检测
FACS Analysis of anti-CD19 CAR expression
1e6 of the anti-CD19 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human CD19 (20-291), His Tag (Cat. No. CD9-HP2H3). PE Streptavidin was used as negative control (QC tested).

Protocol

高亲和力经SPR验证
Biotinylated Human CD19 (20-291), His,Avitag (Cat. No. CD9-H82E9) captured on Biotin CAP - Series S sensor Chip can bind FMC63 MAb (mouse lgG2a) with an affinity constant of 0.255 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol

经ELISA、FACS 和 SPR验证活性显著高于竞品

Binding activity of FITC-Labeled Human CD19, His Tag from two different vendors were evaluated in the ELISA analysis against FMC63 MAb above. The result showed that ACRO's FITC-Labeled Human CD19, His Tag has a much higher binding activity than that of the other vendor.

Protocol

Binding activity of FITC-Labeled Human CD19, His Tag from two different vendors were evaluated in the flow cytometry analysis against anti-CD19-CAR-293 cells above. The result showed that ACRO's FITC-Labeled Human CD19, His Tag has a much higher binding activity than that of the other vendor.

Protocol

Binding activity of Human CD19, His Tag from two different vendors were evaluated by SPR assay against FMC63 MAb. The result showed that ACRO's Human CD19, His Tag can bind FMC63 MAb with an affinity constant of 2.95 nM which is much higher than that of the other vendor.

Protocol

更多CD19相关产品
> 点击查看更多CAR-T靶点信息 > 点击查看更多Anti-FMC63 scFv Ab详细信息-更加灵敏检测Anti-CD19 (FMC63) CAR的特异性抗体
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