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CEACAM-6信息

英文名称:Carcinoembryonic antigen related cell adhesion molecule 6
中文名称:癌胚抗原相关细胞粘附分子6
靶点别称:CEACAM6,CD66c,NCA,Carcinoembryonic Antigen Related Cell Adhesion Molecule 6,Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (Non-Specific Cross Reacting Antigen),Normal Cross-Reacting Antigen,Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6,Non-Specific Crossreacting Antigen,Cluster Of Differentiation 66c,CD66c Antigen,CEAL,CEA Cell Adhesion Molecule 6
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

CEACAM-6产品列表

ACRO质量管理体系
 
评论(4)
CE6-H5223|Human CEACAM-6 / CD66c Protein, His Tag
  1. 188XXXXXXX0
  2. 0人赞
  3. 最快乐的事莫过于实验员老师反应那个产品效果好,项目很顺利了,这款蛋白用于全长抗体种属化改造项目,项目很有难道,如今取得很大进展,非常感谢ACRO的长期帮助
  4. 2024-02-29
CE6-H5223|Human CEACAM-6 / CD66c Protein, His Tag
  1. 199XXXXXXX6
  2. 0人赞
  3. 买人源CD66c蛋白,主要用于动物免疫及血清效价检测,免疫前对蛋白进行了亲和力检测,亲和力完全符合免疫要求,后期效价数据也很可观,三免就达到了建库标准。
  4. 2024-03-27
CE6-H5223|Human CEACAM-6 / CD66c Protein, His Tag
  1. 199XXXXXXX5
  2. 0人赞
  3. 使用CD66c Protein用于该靶点纳米抗体研发项目,亲和力和纯度做过相关验证,数据和coa很吻合,流式结果也相当不错,对应acro产品和服务都很满意,后期会回购。
  4. 2024-02-29
 

CEACAM-6分子别名

CEACAM6,CD66c,CEAL,NCA

CEACAM-6分子背景

Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) is also known as CD66c (Cluster of Differentiation 66c), CEAL, NCA, and is one of seven human CEACAM family members within the immunoglobulin superfamily. In humans, CEACAMs include type I transmembrane proteins (CEACAM1, CEACAM3, and CEACAM4) and GPI-linked molecules (CEACAM5 through CEACAM8). There is no human CEACAM2. CEACAM 6 contains one N-terminal V-type Ig-like domain (N domain), followed by two C2-type Ig-like domains. It shows considerable glycosylation, including (sialyl) LewisX, which mediates binding to E-selectin, galectins and some bacterial fimbrae. CEACAM-6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.

CEACAM-6临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
NEO-201 NEO-201 临床二期 Precision Biologics Inc, 美国国立癌症研究所 头颈部鳞状细胞癌, 子宫肿瘤, 非小细胞肺癌, 宫颈癌 详情
L-DOS-47 L-DOS-47 临床二期 Helix Biopharma 肺腺癌, 胰腺癌, 非小细胞肺癌 详情
EBC-129 EBC-129; EBC129 临床一期 Experimental Drug Development Centre 实体瘤 详情

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