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 > 【CD27】

CD27信息

英文名称：CD27 antigen
中文名称：CD27抗原
靶点别称：CD27 antigen，Tumor necrosis factor receptor superfamily member 7，CD27L receptor，CD27，CD27 Molecule，T-Cell Activation Antigen CD27，TNFRSF7，T14，T Cell Activation Antigen S152，S152. LPFS2，S152，Tp55，Tumor Necrosis Factor Receptor Superfamily， Member 7
上市药物数量：0
临床药物数量：4
最高研发阶段：临床二期

CD27产品列表

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货号 物种 产品描述 蛋白结构 纯度 活性
CD7-C5259
Cynomolgus / Rhesus macaque		 Cynomolgus / Rhesus macaque CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H5257
Human		 Human CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-M5252
Mouse		 Mouse CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H522b
Human		 Human CD27 / TNFRSF7 Protein, His Tag (MALS verified)
CD7-H5254
Human		 Human CD27 / TNFRSF7 Protein, Fc Tag (HPLC verified)
CD7-R52H9
Rat		 Rat CD27 / TNFRSF7 Protein, His Tag
TN7-H82F6
Human		 Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag™
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评论(7)
TN7-H82F6|Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag™
  1. 188XXXXXXX9
    2. 0人赞
  2. The antigen was purchased for phage screening antibody, and after experimental verification, a good screening positive result was obtained. Also used for BLI analysis, human monoclonal antibodies loaded on humanFc biosensors can effectively bind. On elisa blocking assay, the background is very clean compared with another similar product, and this protein used for subsequent screening has obtained the lead
  3. 2023-04-14
TN7-H82F6|Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag™
  1. 159XXXXXXX5
    2. 0人赞
  2. 该Biotinylated Human CD27 / TNFRSF7 Protein是由生物素标记后得到的蛋白，节省了自己生物素标记时间，提高实验效率，且此蛋白性质稳定，纯度高，有利于实验的进行。
  3. 2023-08-18
TN7-H82F6|Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag™
  1. 199XXXXXXX4
    2. 0人赞
  2. 这款生物素化的CD27蛋白用来做Binding实验的开发工作。省去了双靶点分开做Binding的不便之处，该蛋白开发的方法能在一次实验中进行，大大提高了实验效率。
  3. 2025-01-02
查看更多评论
 

CD27分子别名

CD27,TNFRSF7,S152,T14,Tp55

CD27分子背景

CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

CD27临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Boserolimab MK-5890 临床二期 Aduro Biotech Europe Bv 实体瘤, 三阴性乳腺癌, 非小细胞肺癌 详情
Varlilumab CDX-1127 临床二期 Celldex Therapeutics 肺癌, 原发性渗出性淋巴瘤, 胆管上皮癌, 前列腺癌, 胆道癌, 泌尿系肿瘤, 星形细胞瘤, Burkitt淋巴瘤, 非霍奇金淋巴瘤, 胆囊癌, T-细胞淋巴瘤, 浆母细胞淋巴瘤, 泌尿生殖道肿瘤, 胶质瘤, 慢性淋巴细胞白血病, 黑色素瘤, 腺癌, 非小细胞肺癌, T-细胞白血病, 大肠肿瘤, 中枢神经系统淋巴瘤, 皮肤肿瘤, 实体瘤, 肾肿瘤, 头颈癌, 边缘带B细胞淋巴瘤, 卵巢癌, 头颈部鳞状细胞癌, 肾细胞癌, 淋巴瘤样肉芽肿病, 弥漫性大B-细胞淋巴瘤, B-细胞淋巴瘤, 胶质母细胞瘤, 肿瘤, 肾脏疾病, 三阴性乳腺癌, 激素抵抗性前列腺肿瘤, 膀胱癌, 泌尿系疾病, 少突神经胶质瘤, 套细胞淋巴瘤 详情
LOR-S03 CDX-527 临床一期 Celldex Therapeutics 卵巢癌, 肝癌, 实体瘤, 头颈癌, 胃癌, 食道癌, 肾细胞癌, 尿路上皮癌, 乳腺癌, 胆管上皮癌, 结直肠癌, 腹膜癌, 输卵管癌, 非小细胞肺癌 详情
Anti-CD27 monoclonal antibody (Aduro Biotech) BION-1402 临床一期 Aduro Biotech Inc 肿瘤 详情

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