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IL-13 R alpha 2信息

英文名称:Interleukin-13 receptor subunit alpha-2
中文名称:白细胞介素-13受体α2亚基
靶点别称:Interleukin 13 Receptor Alpha 2 Chain,Interleukin-13 Receptor alpha2 Subunit,IL-13RA2,IL-13R-alpha-2,Interleukin-13-binding protein,IL13RA2,Interleukin 13 Receptor Subunit Alpha 2,Interleukin 13 Receptor, Alpha 2,IL-13 Receptor Subunit Alpha-2,Cancer/Testis Antigen 19,IL-13R Subunit Alpha-2,Interleukin-13 Receptor Subunit Alpha-2,Interleukin 13 Binding Protein,CD213a2 Antigen,CD213A2,IL-13R,IL13BP,IL13R,CT19
上市药物数量:0
临床药物数量:5
最高研发阶段:临床一期

IL-13 R alpha 2产品列表

ACRO质量管理体系
 
评论(5)
IL2-H5256|Human IL-13 R alpha 2 Protein, Fc Tag (MALS verified)
  1. 138XXXXXXX9
  2. 1人赞
  3. 我们使用该产品主要用于抗体筛选,是在ELISA实验中用的。该产品特异性好,效价高,相比其它品牌,更少的用量即可达到同等的效价。
  4. 2023-03-29
IL2-H5256|Human IL-13 R alpha 2 Protein, Fc Tag (MALS verified)
  1. 188XXXXXXX0
  2. 0人赞
  3. 购买该蛋白主要用于单克隆抗体研发,在动物免疫阶段,跟其他同行产品对比效价是最好的,周期相较短,有效降低了研发成本,是一款非常不错的产品。
  4. >
  5. 2023-09-22
IL2-H5256|Human IL-13 R alpha 2 Protein, Fc Tag (MALS verified)
  1. 199XXXXXXX5
  2. 0人赞
  3. 没记错的话应该是第二次购买该抗原重组蛋白了,在抗体研发中一直用的acro的蛋白,质量一直很稳定,本次主要用于抗体筛选和验证。
  4. >
  5. 2023-11-13
 

IL-13 R alpha 2分子别名

IL13RA2,CD213A2,CT19,IL-13R,IL13BP

IL-13 R alpha 2分子背景

Interleukin-13 receptor subunit alpha-2 is also known as IL13Rα2, IL13Ra2 cluster of differentiation 213A2, CD213A2, CT19, IL-13R, IL13BP, and is a membrane bound protein that in humans is encoded by the IL13RA2 gene. IL13Rα2 is closely related to IL13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL13 and IL4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13. IL13Rα2 is a component of the cell surface receptors, however, the majority exists in intracellular pools and in soluble form, and thus plays an opposite role as a potent IL13 antagonist compared with IL13Rα1. It also functions as an inhibitor of IL4-dependent pathway probably through the physical interaction between the short intracellular domain of and cytoplasmic domain of IL13Rα2 and the IL4Rα chain. In spite of the failed STAT signaling function, IL13Rα2 dose induce TGF-beta production and fibrosis. Additionally, IL13Rα2has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme.

IL-13 R alpha 2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
IL13Ralpha2 CAR-T cell therapy (Jonsson Comprehensive Cancer Center) 临床一期 Uclas Jonsson Comprehensive Cancer Center 髓母细胞瘤, 室管膜瘤, 胶质母细胞瘤, 黑色素瘤 详情
SNC109 SNC109; SNC-109 临床一期 上海先博生物科技有限公司 胶质母细胞瘤 详情
MB-101 (Mustang Bio) MB-101 临床一期 Mustang Bio Inc, 希望之城国家医疗中心 胶质母细胞瘤, 中枢神经系统肿瘤, 脑癌 详情
IL13Rα2 targeted CAR-T cell(Yooyoung) YYB-103; CLM-103 临床一期 Yooyoung 胶质瘤, 肌萎缩性侧索硬化 详情
MT-026 MT-026 临床一期 苏州茂行生物科技有限公司 胶质瘤 详情

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