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Activin A信息

英文名称:Activin receptor type-1
中文名称:激活素受体-1
靶点别称:ACTR-I,ACVR1,Activin A Receptor Type 1,Serine/Threonine-Protein Kinase Receptor R1,Activin A Receptor, Type I,ACVRLK2,SKR1,Activin A Receptor, Type II-Like Kinase 2,Hydroxyalkyl-Protein Kinase,Activin Receptor Type-1,EC 2.7.11.30,ACVR1A,ACTRI,EC:2.7.11.30,TSR-I,ALK2,TSRI,FOP,Activin Receptors, Type I,ALK-2,Activin receptor type I,TGF-B superfamily receptor type I,EC 2.7.11,Activin receptor-like kinase 2
上市药物数量:1
临床药物数量:5
最高研发阶段:批准上市

Activin A产品列表

ACRO质量管理体系
 
评论(5)
ACA-H421b|Human Activin A / INHBA Protein, premium grade
  1. 188XXXXXXX2
  2. 1人赞
  3. 用该产品当做检测的对照蛋白,这个蛋白纯度、稳定性比较好,用于检测酶联免疫检测其活性很好,性能比较稳定,和其他家产品相比,性价比比较高。
  4. >
  5. 2023-06-21
ACA-H421b|Human Activin A / INHBA Protein, premium grade
  1. 188XXXXXXX2
  2. 1人赞
  3. 用该产品当做检测的对照蛋白,这个蛋白纯度、稳定性比较好,用于检测酶联免疫检测其活性很好,性能比较稳定,和其他家产品相比,性价比比较高。
  4. >
  5. 2023-06-21
ACA-H421b|Human Activin A / INHBA Protein, premium grade
  1. 158XXXXXXX9
  2. 1人赞
  3. 我一直购买Acro产品,这个产品在使用过程中非常稳定,对于实验很有帮助,在测定血清和血浆当中,也有很好的表现!
  4. 2022-12-22
 

Activin A分子别名

Activin A,INHBA

Activin A分子背景

Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.Activins are nonglycosylated homodimers or heterodimers of various β subunits (βA, βB, βC, and βE in mammals), while Inhibins are heterodimers of a unique α subunit and one of the β subunits. Activin A is a widely expressed homodimer of two βA chains. The βA subunit can also heterodimerize with a βB or βC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human βA chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat βA.

Activin A上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Momelotinib Dihydrochloride CYT-387; GS-0387; GSK-3070785 批准上市 Gilead Sciences Inc, Cytopia Pty Ltd Ojjaara United States 骨髓纤维化, 贫血 Glaxosmithkline Llc, Glaxosmithkline Plc 2023-09-15 红细胞增多症, 真性红细胞增多症, 贫血, 肿瘤, 胰腺导管内肿瘤, 骨髓纤维化, 胰腺导管癌, 原发性血小板增多症, 非小细胞肺癌 详情

Activin A临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
BCX-9250 BCX-9250 临床一期 Biocryst Pharmaceuticals Inc 进行性肌肉骨化症 详情
KER-047 KER-047 临床一期 National Center For Advancing Translational Sciences 缺铁性贫血, 进行性肌肉骨化症 详情
Itacnosertib TP-0184 临床一期 Tolero Pharmaceuticals Inc, 大日本住友 实体瘤, 贫血 详情
BLU-782 BLU-782; IPN-60130 临床二期 Blueprint Medicines Corp, Ipsen SA 进行性肌肉骨化症 详情
Zilurgisertib INCB-000928; INCB-00928 临床二期 Incyte Corp 贫血, 真性红细胞增多症, 肾脏疾病, 骨髓增生异常综合征, 异位骨化, 多发性骨髓瘤, 进行性肌肉骨化症, 骨髓纤维化, 原发性血小板增多症 详情

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