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G-CSF信息

英文名称:Granulocyte colony-stimulating factor
中文名称:粒细胞集落刺激因子
靶点别称:Granulocyte colony-stimulating factor,Filgrastim,CSF3,Colony Stimulating Factor 3,Pluripoietin,Lenograstim,Colony Stimulating Factor 3 (Granulocyte),C17orf33,GCSF,Granulocyte-Colony Stimulating Factor,Granulocyte Colony Stimulating Factor,Chromosome 17 Open Reading Frame 33,CSF3OS,G-CSF,MGC45931
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

G-CSF产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
GCF-H5214
Human
Human G-CSF Protein, premium grade
ACRO质量管理体系
 
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G-CSF分子别名

G-CSF,CSF3,C17orf33,CSF3OS,MGC45931

G-CSF分子背景

Granulocyte colony-stimulating factor (G-CSF or GCSF) is also known as colony-stimulating factor 3, CSF3, C17orf33, CSF3OS, GCSF, MGC45931. It is a glycoprotein, growth factor and cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to release them into the blood. G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF regulates them using Janus kinase (JAK)/signal transducer and activator of transcription (STAT) and Ras /mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signal transduction pathway. G-CSF is produced by endothelium, macrophages, and a number of other immune cells. The natural human glycoprotein exists in two forms, a 174- and 180-amino-acid-long protein of molecular weight 19,600 grams per mole. G-CSF can effect on the hematopoietic system and neuronal cells as a neurotrophic factor. The action of G-CSF in the central nervous system is to induce neurogenesis, to increase the neuroplasticity and to counteract apoptosis. G-CSF stimulates the production of white blood cells (WBC). In oncology and hematology, a recombinant form of G-CSF is used with certain cancer patients to accelerate recovery from neutropenia after chemotherapy, allowing higher-intensity treatment regimens. Another form of recombinant human G-CSF called lenograstim is synthesised in Chinese Hamster Ovary cells (CHO cells). The recombinant human G-CSF synthesised in an E. coli expression system is called filgrastim.

G-CSF临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Eflepedocokin alfa F-652 临床二期 Evive Biotech Ltd 酒精性肝炎, 胰腺炎, 新型冠状病毒感染, 移植物抗宿主病, 慢加急性肝衰竭 详情
Pegylated recombinant human granulocyte colony stimulating factor(Sun Yat-sen University) 临床一期 中山大学 血液肿瘤, 鼻咽癌 详情

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