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IL-4信息

英文名称:Interleukin-4
中文名称:白细胞介素-4
靶点别称:B-cell stimulatory factor 1,Pitrakinra,Interleukin-4,Binetrakin,BSF-1,Lymphocyte stimulatory factor 1,IL4,IL-4
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

IL-4产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
IL4-H4218
Human
Human IL-4 /Interleukin-4 Protein,HEK293 expressed,ActiveMax
IL4-H82E0
Human
Biotinylated Human IL-4 / BCGF1 Protein, His Tag, Avi Tag

IL-4 分子别名

IL4,BCGF1,BSF1

IL-4 分子背景

Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

IL-4 参考文献

IL-4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AIR-645 AIR-645; ISIS-369645 临床二期 Ionis Pharmaceuticals, Altair Therapeutics 过敏性哮喘 详情
VAK-694 VAK-694; NVP-VAK-694 临床二期 诺华 季节性过敏性鼻炎 详情
Pascolizumab SB 240683,SB240683 临床二期 葛兰素史克, PDL BioPharma 哮喘
SAR-156597 SAR-156597; SUB-33159 临床二期 赛诺菲 特发性肺纤维化 详情

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