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Gremlin信息

英文名称:Gremlin-1
中文名称
靶点别称:Cell proliferation-inducing gene 2 protein,Cysteine knot superfamily 1, BMP antagonist 1,DAN domain family member 2,Down-regulated in Mos-transformed cells protein,Increased in high glucose protein 2,IHG-2,CKTSF1B1,DAND2,DRM
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

Gremlin产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
GR1-H5254
Human
Human Gremlin / GREM1 Protein, Fc Tag
GR1-H52H3
Human
Human Gremlin / GREM1 Protein, His Tag
ACRO质量管理体系
 
评论(7)
GR1-H5254|Human Gremlin / GREM1 Protein, Fc Tag
  1. 182XXXXXXX6
  2. 0人赞
  3. 本次购买human GREM1蛋白主要用于Elisa检测抗体活性,产品纯度及亲和力都很好,抗体研发项目基本所有蛋白均购自acro,质量值得信赖!
  4. >
  5. 2023-12-13
GR1-H5254|Human Gremlin / GREM1 Protein, Fc Tag
  1. 199XXXXXXX8
  2. 0人赞
  3. 之前在好几个项目中用该货号蛋白都拿到了很不错的结果,剩余的蛋白最近做了流式检测,亲和力还是非常不错,性价比确实很高。
  4. >
  5. 2024-02-16
GR1-H5254|Human Gremlin / GREM1 Protein, Fc Tag
  1. 188XXXXXXX0
  2. 0人赞
  3. 购买此蛋白主要用于抗体研发,亲和力验证等实验,不知道是第几次回购了,研发人员反馈质量杠杠的,每次用完都会第一时间回购
  4. >
  5. 2023-12-15
 

Gremlin分子别名

GREM1,CKTSF1B1,DAND2,DRM,PIG2

Gremlin分子背景

Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

Gremlin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
TST-003 TST-003 临床二期 苏州创胜医药集团有限公司 实体瘤, 肿瘤, 结直肠癌, 转移癌 详情
Ginisortamab UCB-6114 临床二期 Ucb Biopharma Srl 实体瘤 详情

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