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LAIR-1信息

英文名称:Leukocyte-associated immunoglobulin-like receptor 1
中文名称:白细胞相关免疫球蛋白样受体-1
靶点别称:Immunoglobulin Heavy Chain Variable Region,HLAIR1,LAIR1,Leukocyte Associated Immunoglobulin Like Receptor 1,CD305 Antigen,hLAIR1,CD305,Leukocyte-Associated Ig-Like Receptor 1
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

LAIR-1产品列表

ACRO质量管理体系
 
评论(5)
LA1-H5252|Human LAIR1 / CD305 Protein, Fc Tag (MALS verified)
  1. 185XXXXXXX2
  2. 2人赞
  3. 挺漂亮的cruve,第一遍就做出来了,4度保存了一个月拿出来重复了,依旧一样,稳定性还是蛮好的,后续打算用这个蛋白建立blocking assay,希望我的实验一切顺利
  4. >
  5. 2021-11-12
LA1-H5252|Human LAIR1 / CD305 Protein, Fc Tag (MALS verified)
  1. 135XXXXXXX7
  2. 0人赞
  3. 赶上公司做活动 做SPR还可以免费用他们家的蛋白 感觉简直是太赚了 第一次就做出来了 为了稳定结果 我要求重复几次 公司的技术老师很负责 直到做到满意为止 蛋白也好用 价格也不贵
  4. 2020-02-20
CD5-H52H1|Human LAIR1 / CD305 Protein, His Tag
  1. 153XXXXXXX5
  2. 0人赞
  3. 采购该Human LAIR1-His蛋白(CD5-H52H1),用于小鼠免疫和噬菌体文库抗体的发现,可以产生一定的免疫反应,并可以用于基于ELISA方法的抗体发现方法。
  4. 2022-06-05
 

LAIR-1分子别名

LAIR1,CD305

LAIR-1分子背景

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity.
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.

LAIR-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
NC-410 NC-410 临床二期 Nextcure Inc 卵巢癌, 实体瘤, 胃癌, 结直肠癌 详情
NGM-438 NGM-438 临床一期 Merck & Co Inc, Ngm Biopharmaceuticals Inc 卵巢癌, 实体瘤, 食道癌, 胃癌, 肾细胞癌, 头颈部鳞状细胞癌, 胰腺癌, 尿路上皮癌, 间皮组织肿瘤, 胆管上皮癌, 乳腺癌, 前列腺癌, 结直肠癌, 非小细胞肺癌, 宫颈癌, 黑色素瘤 详情

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