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 > 【CD96】重组蛋白信息

CD96产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
TAE-H5252
Human
Human CD96 / TACTILE Protein, Mouse IgG2a Fc Tag, low endotoxin
TAE-H52H0
Human
Human CD96 / TACTILE Protein, His Tag
TAE-H82E3
Human
Biotinylated Human CD96 / TACTILE Protein, His,Avitag

CD96 分子别名

TACTILE

CD96 分子背景

The progression of pancreatic cancer (PC) is significantly associated with tumor immune escape, which may be associated with nature killer (NK) cell dysfunction. CD226, CD96, and TIGIT, which share the ligand CD155, play important roles in the regulation of NK cell function. The present study was conducted to investigate the roles of these molecules in NK cells from PC patients. TIGIT and CD96 together with the co-stimulatory receptor CD226 form a pathway that is analogous to the CD28/CTLA-4 pathway, in which shared ligands and differential receptor:ligand affinities fine-tune the immune response. Although the roles of TIGIT and CD96 as immune checkpoint receptors in T cell and natural killer cell biology are just beginning to be uncovered, accumulating data support the targeting of these receptors for improving anti-tumor immune responses. A clear understanding of the immune cell populations regulated by TIGIT and CD96 is key to the design of immunotherapies that target these receptors in combination with other existing immune checkpoint blockade therapies. The dysfunction of CD96 may trigger C syndrome: A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and low-set, posteriorly rotated ears.

CD96 参考文献

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