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IL-5信息

英文名称:Interleukin-5
中文名称:白细胞介素-5
靶点别称:IL-5,IL5,TRF,T-cell replacing factor,Eosinophil differentiation factor,B-cell differentiation factor I,Interleukin-5
上市药物数量:2
临床药物数量:4
最高研发阶段:批准上市

IL-5产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
IL5-H52H3
Human
Human IL-5 Protein, His Tag
IL5-H82Q5
Human
Biotinylated Human IL-5 Protein, His,Avitag
 
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IL-5 Molecule Synonym Name

IL-5,TRF,IL5,Interleukin-5

IL-5 分子背景

Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells. IL-5 is a 115-amino acid (in human, 133 in the mouse) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a homodimer. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. Given the high concordance of eosinophils and, in particular, allergic asthma pathology, it has been widely speculated that eosinophils have an important role in the pathology of this disease. Drugs that target IL-5 are mepolizumab and reslizumab.

IL-5 参考文献

IL-5上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Mepolizumab 美泊利单抗 SB-240563; 240563,SB240563 批准上市 葛兰素史克 NUCALA fda 哮喘 GLAXOSMITHKLINE LLC 2015-11-04 嗜酸性粒细胞肉芽肿, 哮喘 详情
Reslizumab CDP-835; CEP-38072; CTx-55700; SCH-5570; SCH-55700; TRFK-5,CDP835; CEP38072; CTx55700; SCH5570; SCH55700; TRFK5 批准上市 梯瓦 CINQAIR fda 哮喘 TEVA RESPIRATORY LLC 2016-03-23 哮喘 详情

IL-5临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
GCC-AP0341 GCC-AP0341,GCCAP0341,GCC AP0341 临床前 田边三菱制药 支气管哮喘
SHR-1703 SHR-1703 临床一期 上海恒瑞, 江苏恒瑞, 苏州盛迪亚 不明
LP-0058 LP-0058; LEO-32731,LP0058,LEO32731 临床二期 利奥制药 银屑病, 特应性皮炎 详情
Recombinant anti-IL-5 humanized monoclonal antibody (Shanghai CP Guojian) 临床一期 三生国健药业(上海) 自身免疫疾病, 哮喘

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