2024年10月8日，宜联生物与安进宣布合作：双方将共同推进靶向B7-H3的ADC药物 YL201与DLL3/CD3双抗Imdelltra在广泛性非小细胞肺癌治疗中的联合应用研究。双方将结合在ADC和抗体药领域的优势，通过多靶点联合治疗策略为难治性非小细胞肺癌患者提供更多治疗选择。

B7-H3和DLL3是近年来备受关注的肿瘤免疫靶点。B7-H3在多种实体肿瘤中高表达，其ADC药物能精准靶向肿瘤细胞；DLL3/CD3双抗则通过同时靶向DLL3和CD3，激活免疫系统杀伤肿瘤。此次合作旨在探索B7-H3 ADC与DLL3/CD3双抗的协同效应，利用不同机制的联合提高治疗效果。B7-H3 ADC精准递送药物，减少正常组织损伤；DLL3/CD3双抗则激活免疫系统消灭癌细胞，两者结合有望克服单一疗法的局限，为患者提供更持久的治疗反应。

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小细胞肺癌（SCLC）是一种高度侵袭性的神经内分泌肿瘤，预后较差。大约三分之二的患者在确诊时已发展为广泛期（ES-SCLC），这一阶段的特点是癌细胞已发生远端转移，或超出了单一放疗的适用范围。相比之下，广泛期患者生存预期比局限期（LS-SCLC）患者更低。

目前，靶向DLL3生物药开发管线共计25个，其中上市药物1个，临床前及临床阶段24个。药物类型包括：抗体药（单抗，双抗，三抗）、抗体偶联药物（Antibody-drug conjunct, ADC）、CAR-T、CAR-NK、细胞疗法。

靶向DLL3生物药开发情况

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Immobilized Biotinylated Human DLL3, His,Avitag (Cat. No. DL3-H82E4) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Anti-DLL3 Antibody (specific Binding EGFs of DLL3), Human IgG1 with a linear range of 0.1-4 ng/mL (QC tested).

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Immobilized Human DLL3, His Tag (Cat. No. DL3-H52H4), multiple batches of the product were compared and tested by ELISA, and its binding activity is stable.

Human Jagged 1, His Tag (Cat. No. JA1-H52H9) immobilized on CM5 Chip can bind Human NOTCH1, Fc Tag (Cat. No. NO1-H5255) with an affinity constant of 5.13 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

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Loaded Human NOTCH2, Fc Tag (Cat. No. NO2-H5255) on Protein A Biosensor, can bind Human DLL4, His Tag (Cat. No. DL4-H5227) with an affinity constant of 77.6 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

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Quantitative Analysis of Bispecific T-cell Engager (CD3 X BCMA) in human serum.
Immobilized Human BCMA, His Tag (Cat. No. BCA-H522y) at 2 μg/mL, add increasing concentrations of Bispecific T cell Engager (CD3 X BCMA) in 10% human serum and then add Biotinylated Human CD3E&CD3D Heterodimer Protein, His,Avitag&Tag Free (Cat. No. CDD-H82W6) at 0.2 μg/mL. Detection was performed using HRP-conjugated streptavidin with sensitivity of 15 ng/mL (Routinely tested).

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The purity of Mouse CD3 epsilon&CD3 gamma Heterodimer Protein, His Tag&Flag Tag (MALS verified) (Cat. No. CDG-M52D2) is greater than 95% verified by SDS-PAGE and more than 95% verified by SEC-MALS.

Expression analysis of human DLL3 on CHO/Human DLL3 Stable Cell Line by FACS.
Cell surface staining was performed on CHO/Human DLL3 Stable Cell Line  (Cat. No. SCCHO-ATP111) or negative control cell using anti-human DLL3 antibody followed by staining with PE anti-human IgG Fc Antibody.

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