ActiveMax®是ACROBiosystems百普赛斯基于高活性重组蛋白和生物相容性磁珠开发生产技术平台,开发的一系列细胞激活、培养等应用场景的磁珠产品品牌,如靶点特异性激活磁珠、CD3/CD28抗体偶联磁珠等,经严格质量控制,具有无动物源性、无菌、无支原体、超低内毒素等安全特性,适用于免疫细胞治疗相关研究和临床前工艺开发,且可定制GMP级别磁珠以应用于商业化生产的无缝衔接。
此外,我们还提供无菌细胞级别链酶亲和素磁珠,可帮助您快速实现各种细胞级别蛋白/抗体偶联磁珠的个性化制备。
细胞激活
利用基于磁珠偶联的抗原多聚体的方式可很好的特异性激活CAR-T细胞。
CAR细胞富集
特异性靶点磁珠可用于富集低丰度CAR细胞或稀有CAR-T细胞。
CAR细胞体外分析
采用特异性靶点偶联磁珠与CAR-T 细胞共孵育后,进行如T细胞激活、增殖、细胞因子释放等体外分析来定位产品表征及放行测试。
ActiveMax Streptavidin coupled μbeads, premium grade coupled with protein. 40ug of the biotinylated human BCMA protein (Cat. No. BCA-H82E4) was added to 1mg of ActiveMax Streptavidin coupled μbeads, premium grade (for cells) (Cat. No. MBS-C009), mix well and incubate for 60 mins at room temperature. And then the coupled μbeads were fluorescently stained using PE labeled anti-human BCMA antibody and analyzed by flow cytometry.
ActiveMax Streptavidin coupled μbeads, premium grade coupled with human BCMA protein. The biotinylated human BCMA protein (Cat. No. BCA-H82E4) in serial dose was added to 1mg of ActiveMax Streptavidin coupled μbeads, premium grade (for cells) (Cat. No. MBS-C009), mix well and incubate for 60 mins at room temperature. And then the unbound protein in supernatant measured by Micro BCA Protein Assay Kit was subtracted to calculate the BCMA protein coupled amount on the μbeads (loaded capacity).
ActiveMax Streptavidin coupled μbeads, premium grade coupled with antibody. 50ug of the biotinylated anit-FMC63 Antibody (Cat. No. FM3-BY54) was added to 1mg of ActiveMax Streptavidin coupled μbeads, premium grade (for cells) (Cat. No. MBS-C009), mix well and incubate for 60 mins at room temperature. And then the coupled μbeads were fluorescently stained using PE labeled anti-mouse Fc antibody and analyzed by flow cytometry.
ActiveMax Streptavidin coupled μbeads, premium grade coupled with antibody. The anit-FMC63 Antibody (Cat. No. FM3-BY54) in serial dose was added to 1mg of ActiveMax Streptavidin coupled μbeads, premium grade (for cells) (Cat. No. MBS-C009), mix well and incubate for 60 mins at room temperature. And then the unbound protein in supernatant measured by Micro BCA Protein Assay Kit was subtracted to calculate the antibody coupled amount on the μbeads (loaded capacity).
我们致力于为细胞疗法及其他应用场景提供高度个性化的解决方案,依托ActiveMax平台,我们可根据您的具体研究需求提供定制化的偶联磁珠产品,以助力您的药物研发进程。
可根据您的实际需求定制不同结合方法、不同尺寸的磁珠。
磁珠选取灵活
严格的质量控制,可满足无菌、无动物来源、超低内毒素等质量标准。
质量控制严格
拥有数千种高品质蛋白/抗体,并在偶联磁珠定制服务中免费提供。
蛋白种类丰富
完善的GMP质量管理体系,支持您从早期开发顺利过渡到临床生产。
支持GMP级临床生产