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>产品&服务 > 神经抗体 | 精准检测神经细胞标志物

神经抗体 | 精准检测神经细胞标志物

神经抗体 | 精准检测神经细胞标志物
背景介绍
产品列表
验证数据
背景介绍
神经抗体 | 精准检测神经细胞标志物
中枢神经系统中神经元与神经胶质细胞的发育过程
https://doi.org/10.3389/fcell.2021.754606
由神经细胞形成的神经系统是大脑执行功能的核心，不同种类的神经细胞发挥着不同的生理功能，准确区分这些神经细胞对神经科学研究具有重要的指导意义。神经抗体能够特异性地标记和识别神经细胞上的特定分子，帮助研究人员准确地区分和鉴定不同类型的神经细胞，进而深入研究它们在神经系统中的作用和相互关系。其次，许多神经退行性疾病，如阿尔茨海默病（AD）、帕金森病（PD）等，都与特定神经细胞类型的损伤或功能障碍有关。通过使用神经抗体，能够监测这些神经细胞的变化，评估疾病的进展程度，并为患者提供更为精准的诊断和治疗方案。此外，神经抗体还在神经发育、神经再生以及神经药物研发等领域具有广泛的应用前景。
Aneuro作为ACROBiosystems百普赛斯专注于神经领域的品牌，推出了一系列针对神经科学领域的专用神经抗体，这些抗体具有高特异性、高灵敏度和高稳定性。经过严格验证，它们能够特异性地识别和结合大脑类器官中表达的神经标志物，助力更全面地理解和研究神经细胞的生物学特性、功能及其在神经退行性疾病中的作用机制。
产品列表
分子 货号 产品描述 应用
GFAP GFP-S453 Polyclonal GFAP Antibody, Rabbit IgG 与GFAP分子特异性结合，鉴定星形胶质细胞
NG2/Cspg4 NG4-S455 Polyclonal NG2/Cspg4 Antibody, Rabbit IgG 与NG2分子特异性结合，鉴定少突胶质前体细胞
Olig2 OL2-S456 Polyclonal Olig2 Antibody, Rabbit IgG 与Olig2分子特异性结合，鉴定少突胶质细胞
Tbr1 TB1-S457 Polyclonal Tbr1 Antibody, Rabbit IgG 与Tbr1分子特异性结合，鉴定未成熟神经元
NeuN/Rbfox3 NE3-S454 Monoclonal NeuN/Rbfox3 Antibody, Mouse IgG1 与NeuN分子特异性结合，鉴定成熟神经元
验证数据
经免疫荧光验证，神经抗体可与大脑类器官的标志物特异性结合
经免疫荧光验证，神经抗体可与大脑类器官的标志物特异性结合

Immunofluorescent staining (10X) of cerebral organoid-derived cells (Cat. No. CIPO-BWL001K) labeling Tbr1 (Red) with purified Polyclonal Tbr1 Antibody, Rabbit IgG (Cat. No. TB1-S457) at 1:200 dilution. DAPI (blue) was used as nuclear counterstain.

经免疫荧光验证，神经抗体可与大脑类器官的标志物特异性结合

Immunofluorescent staining (10X) of cerebral organoid-derived cells (Cat. No. CIPO-BWL001K) labeling NeuN (Red) with purified Monoclonal NeuN/Rbfox3 Antibody, Mouse IgG1 (Cat. No. NE3-S454) at 1:500 dilution. DAPI (blue) was used as nuclear counterstain.

经免疫荧光验证，神经抗体可与大脑类器官的标志物特异性结合

Immunofluorescent staining (10X) of cerebral organoid-derived cells (Cat. No. CIPO-BWL001K) labeling GFAP (Red) with purified Polyclonal GFAP Antibody, Rabbit IgG (Cat. No. GFP-S453) at 1:200 dilution. DAPI (blue) was used as nuclear counterstain.

经免疫荧光验证，神经抗体可与大脑类器官的标志物特异性结合

Immunofluorescent staining (10X) of cerebral organoid-derived cells (Cat. No. CIPO-BWL001K) labeling NG2 (Red) with purified Polyclonal NG2/Cspg4 Antibody, Rabbit IgG (Cat. No. NG4-S455) at 1:200 dilution. DAPI (blue) was used as nuclear counterstain.

经免疫荧光验证，神经抗体可与大脑类器官的标志物特异性结合

Immunofluorescent staining (10X) of cerebral organoid-derived cells (Cat. No. CIPO-BWL001K) labeling Olig2 (Red) with purified Polyclonal Olig2 Antibody, Rabbit IgG (Cat. No. OL2-S456) at 1:200 dilution. DAPI (blue) was used as nuclear counterstain.

参考文献
  • 1. Neely S A, Lyons D A. Insights into central nervous system glial cell formation and function from zebrafish[J]. Frontiers in Cell and Developmental Biology, 2021, 9: 754606. https://doi.org/10.3389/fcell.2021.754606
  • 2. Yokoo H, Nobusawa S, Takebayashi H, et al. Anti-human Olig2 antibody as a useful immunohistochemical marker of normal oligodendrocytes and gliomas[J]. The American journal of pathology, 2004, 164(5): 1717-1725. https://doi.org/10.1016/S0002-9440(10)63730-3
  • 3. Zhao W, Dumanis S B, Tamboli I Y, et al. Human APOE genotype affects intraneuronal Aβ1–42 accumulation in a lentiviral gene transfer model[J]. Human molecular genetics, 2014, 23(5): 1365-1375. https://doi.org/10.1093/hmg/ddt525
  • 4. Yu L, Chen C, Wang L F, et al. Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-κB and STAT3 in transient focal stroke[J]. PloS one, 2013, 8(2): e55839. https://doi.org/10.1371/journal.pone.0055839
  • 6. Englund C, Fink A, Lau C, et al. Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in develo** neocortex[J]. Journal of Neuroscience, 2005, 25(1): 247-251. https://doi.org/10.1523/JNEUROSCI.2899-04.2005
  • 7. Jurga A M, Paleczna M, Kadluczka J, et al. Beyond the GFAP-astrocyte protein markers in the brain[J]. Biomolecules, 2021, 11(9): 1361. https://doi.org/10.3390/biom11091361
  • 8. Alekseeva O S, Gusel’nikova V V, Beznin G V, et al. Prospects for the application of neun nuclear protein as a marker of the functional state of nerve cells in vertebrates[J]. Journal of Evolutionary Biochemistry and Physiology, 2015, 51: 357-369. https://doi.org/10.1134/S0022093015050014
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