“CAR”是CAR细胞疗法成功的关键所在，也是推动该疗法变革性进展的核心驱动力。为助力CAR细胞疗法的开发，ACROBiosystems百普赛斯倾力打造一系列抗CAR Linker抗体。这些抗体经过精密设计，精准靶向常用的G4S Linker和Whitlow/218 Linker，覆盖PE、APC、Alexa Fluor™等多种荧光标记形式，为CAR分子表征和功能检测提供突破性解决方案。此外，我们推出的 Premium-grade抗CAR Linker抗体 ，通过严苛的质量控制，展现出卓越的性能，广泛适用于细胞激活、分选等关键应用场景。凭借技术创新与高品质保障，ACROBiosystems以领先的解决方案赋能CAR细胞疗法研发，助力科学家加速从基础研究到临床转化的每一步，为细胞疗法的未来注入新动能。
产品列表
| CAR Linker |
Cat. No. |
Species |
Product Description |
| G4S linker |
G4S-PFMY25 |
Rabbit |
PE-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (0.03% Proclin) |
| G4S linker |
G4S-AFMY25 |
Rabbit |
APC-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (0.03% Proclin) |
| G4S linker |
G4S-FAFYP1 |
Rabbit |
FITC-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (0.03% Proclin) |
| G4S linker |
G4S-AEFYP1 |
Rabbit |
Alexa Fluor™ 555-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (0.03% Proclin) |
| G4S linker |
G4S-ABFYP1 coming soon! |
Rabbit |
Alexa Fluor™ 647-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (0.03% Proclin) |
| G4S linker |
G4S-BLM25G0 |
Rabbit |
Biotinylated Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016), premium grade |
| G4S linker |
G4S-CFM25G0 |
Rabbit |
PE-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016), premium grade |
| G4S linker |
G4S-HFM25G0 |
Rabbit |
APC-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016), premium grade |
产品优势
高亲和力： 基于单B细胞抗体平台开发的兔单克隆抗体。
高特异性： 与外周血单核细胞（PBMCs）无非特异性结合。
种属、亚型通用： 不受单链抗体（scFv）亚型和种属限制，可兼容各种单链抗体。
体内外通用： 不受抗原封闭和血清影响，体内和体外环境均可适用。
PG级产品： 适用于CAR细胞激活、分选及富集。
验证数据
经类CAR细胞批检放行
经流式验证，PE荧光标记兔抗G4S Linker抗体可高特异与Anti-CD19 (G4S)4、Anti-MSLN (G4S)3、Anti-CD22 (G4S)3 等类CAR细胞结合。
Flow cytometric analysis of Anti-CD19 CAR-293/Anti-MSLN CAR-293//Anti-CD2 CAR-293 cells staining with PE-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016) (Cat. No. G4S-PFMY25) at 1:50 dilution (2 μL of the antibody stock solution corresponds to labeling of 1e6 cells in a final volume of 100 µL), compared with isotype control antibody. PE signal was used to evaluate the binding activity.
极低非特异信号：经PBMC双染验证
Non-specificity of PE-Labeled Monoclonal Anti-G4S linker Antibody, Rabbit IgG (016), premium grade (Cat. No. G4S-CFM25G0) binding to CD3+ cells present in human PBMC. 5e5 of human PBMCs were simultaneously stained with FITC-labeled anti-CD3 antibody and PE-Labeled Anti-G4S linker Antibody (016) (2 μL of the antibody stock solution corresponds to labeling of 5e5 cells in a final volume of 100 µL) and washed and then analyzed with FACS. Both FITC and PE positive signals was used to evaluate the non-specific binding activity to human CD3+ cells (QC tested).
阳性信号高于竞品
Flow cytometric analysis of Anti-CD19 CAR-293 cells staining with PE-Labeled Monoclonal Anti-G4S linker Antibodies (Cat. No. G4S-PFMY25). PE signal was used to evaluate the binding activity of anti-G4S linker antibody. The biological activity level of ACRO is superior to competitor C.
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Star Ribbon预染蛋白Marker蛋白质标记物是生物研究和药物开发的重要组成部分。无论是用于蛋白质电泳还是western blot，我们的预染色蛋白质标记物帮助您快速确定目标蛋白质的分子量或评估转移效率。Fc受体蛋白治疗性抗体的功效取决于Fab片段及其对目标抗原的结合活性，还取决于Fc片段及其与关键Fc受体的相互作用。因此，在抗体工程中候选物必须针对一系列受体进行测试。探索我们的重组Fc受体蛋白质的全面收藏！
膜杰作
Star Staining
