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Human Tau-441 / 2N4R Protein, His Tag

分子别名(Synonym)

DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU

表达区间及表达系统(Source)

Human Tau-441, His Tag (TAU-H51H3) is expressed from E. coli cells. It contains AA Met 1 - Leu 441 (Accession # P10636-8).

Predicted N-terminus: Met

Request for sequence

蛋白结构(Molecular Characterization)

Tau Structure

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 47.9 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE).

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Tau SDS-PAGE

Human Tau-441, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

 

活性(Bioactivity)-ELISA

Tau ELISA

Immobilized Human Tau-441, His Tag (Cat. No. TAU-H51H3) at 5 μg/mL (100 μL/well) can bind Tau Monoclonal Antibody with a linear range of 1-20 ng/mL (Routinely tested).

Protocol

 

背景(Background)

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441", which consisting of 441 amino acid. Tau-441 is a potential therapeutic target for pathogenesis.

 

前沿进展

 
 
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Tau靶点信息
英文全称:Microtubule-associated protein tau
中文全称:微管相关蛋白tau
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:34详情
最高研发阶段:批准上市
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