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Human CD6 / TP120 Protein, His Tag

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分子别名(Synonym)

CD6,TP120,T12

表达区间及表达系统(Source)

Human CD6, His Tag (CD6-H52H7) is expressed from human 293 cells (HEK293). It contains AA His 18 - Glu 398 (Accession # P30203-1).

Predicted N-terminus: His 18

Request for sequence

蛋白结构(Molecular Characterization)

Online(His 18 - Glu 398) P30203-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 42.5 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human CD6, His Tag (Cat. No. CD6-H52H7) SDS-PAGE gel

Human CD6, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

背景(Background)

CD6 (Cluster of Differentiation 6) is a cell surface glycoprotein that is involved in T cell activation and a member of the scavenger receptor cysteine rich protein superfamily (SRCRSF). CD6 is expressed at low levels on immature thymocytes and at high levels on mature thymocytes. The majority of peripheral blood T cells, a subset of B cells, and a subset of neuronal cells express CD6. CD6 appears to play a role as both a costimulatory molecule in T cell activation and as an adhesion receptor. Studies demonstrating a mitogenic effect for T cells with some CD6 specific monoclonal antibodies, in conjunction with either accessory cells or PMA and anti-CD2 mAb, support the concept of CD6 as a co stimulatory molecule.

 

 

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CD6靶点信息
英文全称:T-cell differentiation antigen CD6
中文全称:T细胞分化抗原CD6
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:0详情
最高研发阶段:批准上市
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