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SARS-CoV-2 (COVID-19) NSP8 Protein, His Tag

分子别名(Synonym)

NSP8,nsp8,Non-structural protein 8

表达区间及表达系统(Source)

SARS-CoV-2 NSP8, His Tag (NS8-C5149) is expressed from E. coli cells. It contains AA Ala 1 - Gln 198 (Accession # YP_009725304.1).

Predicted N-terminus: Met

Request for sequence

蛋白结构(Molecular Characterization)

NSP8 Structure

This protein carries a polyhistidine tag at the N-terminus

The protein has a calculated MW of 23.9 kDa. The protein migrates as 22-25 kDa under reducing (R) condition (SDS-PAGE).

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Supplied as 0.2 μm filtered solution in 20 mM Tris, 250 mM NaCl, pH8.5 with glycerol as protectant.

Contact us for customized product form or formulation.

运输(Shipping)

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储(Storage)

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. The product MUST be stored at -70°C or lower upon receipt;
  2. -70°C for 3 months under sterile conditions.
 

电泳(SDS-PAGE)

NSP8 SDS-PAGE

SARS-CoV-2 NSP8, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

背景(Background)

NSP8, forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers. To ultimately combat the emerging COVID-19 pandemic, it is desired to develop an effective and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 coronavirus. By investigating the entire proteome of SARS-CoV-2, six proteins, including the S protein and five non-structural proteins (nsp3, 3CL-pro, and nsp8-10) were predicted to be adhesins, which are crucial to the viral adhering and host invasion. The S, nsp3, and nsp8 proteins were also predicted by Vaxign-ML to induce high protective antigenicity.

 

 

前沿进展

 
 
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NSP8靶点信息
英文全称:SARS-CoV-2-3C-like-proteinase
中文全称:SARS冠状病毒2-3C样蛋白酶
种类:Homo sapiens
上市药物数量:5详情
临床药物数量:27详情
最高研发阶段:批准上市
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