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 >  Protein>FGF-21 >FG1-H5243

Human FGF-21 Protein, His Tag

分子别名(Synonym)

FGF-21, FGF21

表达区间及表达系统(Source)

Human FGF-21, His Tag (FG1-H5243) is expressed from human 293 cells (HEK293). It contains AA His 29 - Ser 209 (Accession # Q9NSA1-1).

Predicted N-terminus: His

Request for sequence

蛋白结构(Molecular Characterization)

Online(His 29 - Ser 209) Q9NSA1-1

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 21.3 kDa. The protein migrates as 25-28 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human FGF-21, His Tag (Cat. No. FG1-H5243) SDS-PAGE gel

Human FGF-21, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

背景(Background)

Fibroblast growth factor 21 (FGF21), which stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression. FGF21 has been shown to protect animals from diet-induced obesity when overexpressed in transgenic mice. It also lowers blood glucose and triglyceride levels when administered to diabetic rodents, suggesting it may exhibit the therapeutic characteristics necessary for effective treatment of diabetes. Treatment of animals with FGF21 results in increased energy expenditure, fat utilisation and lipid excretion. FGF21 is most abundantly expressed in the liver, and also expressed in the thymus at lower levels.

 

 

前沿进展

 
 
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FGF-21靶点信息
英文全称:Fibroblast growth factor 21
中文全称:成纤维细胞生长因子-21
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:8详情
最高研发阶段:临床三期
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