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Cynomolgus CD79B Protein, His Tag (MALS verified)

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分子别名(Synonym)

CD79b,B29,IGB,Ig-beta

表达区间及表达系统(Source)

Cynomolgus CD79B, His Tag (CDB-C52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 30 - Asp 161 (Accession # A0A2K5WTH8-1).

Predicted N-terminus: Ala 30

Request for sequence

蛋白结构(Molecular Characterization)

Online(Ala 30 - Asp 161) A0A2K5WTH8-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 17.2 kDa. The protein migrates as 27-32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Cynomolgus CD79B, His Tag (Cat. No. CDB-C52H3) SDS-PAGE gel

Cynomolgus CD79B, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS

Cynomolgus CD79B, His Tag (Cat. No. CDB-C52H3) MALS images

The purity of Cynomolgus CD79B, His Tag (Cat. No. CDB-C52H3) is more than 90% and the molecular weight of this protein is around 20-40 kDa verified by SEC-MALS.

Report

背景(Background)

B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

 

 

前沿进展

 
 
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CD79B靶点信息
英文全称:B-cell antigen receptor complex-associated protein beta chain
中文全称:B细胞抗原受体复合物相关蛋白β链
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:9详情
最高研发阶段:批准上市
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