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Mouse GCGR / Glucagon receptor Protein, Fc Tag

分子别名(Synonym)

Glucagon R, GCGR,Glucagon receptor

表达区间及表达系统(Source)

Mouse GCGR, Fc Tag (GCR-M5254) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Lys 137 (Accession # Q61606-1).

Predicted N-terminus: Ala 27

蛋白结构(Molecular Characterization)

Online(Ala 27 - Lys 137) Q61606-1

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 39.5 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by reduced SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Mouse GCGR, Fc Tag (Cat. No. GCR-M5254) SDS-PAGE gel

Mouse GCGR, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

背景(Background)

G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.

 

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GCGR靶点信息
英文全称:Glucagon receptor
中文全称:胰高血糖素受体
种类:Homo sapiens
上市药物数量:5详情
临床药物数量:22详情
最高研发阶段:批准上市
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