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Mouse Anti-MMAE Antibody, Mouse IgG1

表达区间及表达系统(Source)

Monoclonal Anti-MMAE Antibody, Mouse IgG1 (MME-M5252) is expressed from human 293 cells.

亚型(Isotype)

Mouse IgG1 / kappa

特异性(Specificity)

Specifically recognizes the target-MMAE.

应用说明(Application)

This Monoclonal anti-MMAE antibody is designed for use in ELISA and PK environment.

纯度(Purity)

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

运输(Shipping)

This product is supplied and shipped as sterile liquid solution with dry ice, please inquire the shipping cost.

制剂(Formulation)

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

存储(Storage)

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. The product MUST be stored at -70°C or lower upon receipt;
  2. -70°C for 3 months under sterile conditions.
 

电泳(SDS-PAGE)

Mouse Anti-MMAE Antibody, Mouse IgG1 (Cat. No. MME-M5252) SDS-PAGE gel

Mouse Anti-MMAE Antibody, Mouse IgG1 on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS

Mouse Anti-MMAE Antibody, Mouse IgG1 (Cat. No. MME-M5252) MALS images

The purity of Mouse Anti-MMAE Antibody, Mouse IgG1 (Cat. No. MME-M5252) was more than 90% and the molecular weight of this protein is around 134-163 kDa verified by SEC-MALS.

Report

 

活性(Bioactivity)-ELISA

Biotinylated Human ELISA

Immobilized Disitamab Vedotin (RC48) at 1 μg/mL (100 μL/well) can bind Mouse Anti-MMAE Antibody, Mouse IgG1 (Cat. No. MME-M5252) with a linear range of 0.2-2 ng/mL (QC tested).

Protocol

背景(Background)

Monomethyl auristatin E (MMAE) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types. Anti-MMAE antibody is a Mouse monoclonal antibody. This antibody has been shown to work in applications such as: PK, PD, Immunoassay and ELISA.

 

前沿进展

 
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