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Cynomolgus LILRB1 / CD85j / ILT2 Protein, His Tag

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分子别名(Synonym)

CD85J,LILRB1,CD85,ILT2,LIR1,MIR7

表达区间及表达系统(Source)

Cynomolgus LILRB1, His Tag (CDJ-C52H3) is expressed from human 293 cells (HEK293). It contains AA Gly 41 - His 474 (Accession # XP_045236898.1).

Predicted N-terminus: Gly 41

蛋白结构(Molecular Characterization)

Online-Res(Gly 41 - His 474) XP_045236898.1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 49.0 kDa.

内毒素(Endotoxin)

制剂(Formulation)

Please contact us for detailed information.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

背景(Background)

CD85 antigen-like family member J (CD85J) is also known as Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1 or LIR-1), Immunoglobulin-like transcript 2 (ILT-2), Monocyte/macrophage immunoglobulin-like receptor 7 (MIR7), which belongs to leukocyte immunoglobulin-like receptor (LIR) family. CD85J / LILRB1 Contains 4 Ig-like C2-type (immunoglobulin-like) domains. CD85J / LIR-1 is expressed predominantly on B-cells and monocytes. CD85J is receptor for class I MHC antigens and recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles and is also receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. CD85J / LILRB1 interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. CD85J / LILRB1 inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

 

前沿进展

 
 
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LILRB1靶点信息
英文全称:Leukocyte immunoglobulin-like receptor B1
中文全称:白细胞免疫球蛋白样受体B1
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:1详情
最高研发阶段:临床二期
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