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Mouse IL-11 R alpha Protein, His Tag

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分子别名(Synonym)

IL-11 R alpha,IL-11 RA,IL11RA,Interleukin-11 receptor subunit alpha,IL-11 receptor subunit alpha,IL-11R subunit alpha,IL-11R-alpha

表达区间及表达系统(Source)

Mouse IL-11 R alpha, His Tag (ILR-M52H9) is expressed from human 293 cells (HEK293). It contains AA Cys 26 - Gln 367 (Accession # Q64385-1).

Predicted N-terminus: Cys 26

蛋白结构(Molecular Characterization)

Online-Res(Cys 26 - Gln 367) Q64385-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 38.0 kDa.

内毒素(Endotoxin)

制剂(Formulation)

Please contact us for detailed information.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

背景(Background)

Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.

 

前沿进展

 
 
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IL-11 R alpha靶点信息
英文全称:Interleukin 11 receptor alpha
中文全称:白细胞介素-11受体α
种类:Homo sapiens
上市药物数量:10详情
临床药物数量:1详情
最高研发阶段:批准上市
前沿进展

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