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 >  Protein>OSMR >OSR-H52H9

Human OSMR beta Protein, His Tag (MALS verified)

分子别名(Synonym)

Oncostatin-M-specific receptor subunit beta,Interleukin-31 receptor subunit beta,IL-31 receptor subunit beta,IL-31R subunit beta,IL-31R-beta,IL-31RB,OSMR,OSMRB

表达区间及表达系统(Source)

Human OSMR, His Tag (OSR-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 28 - Met 740 (Accession # Q99650-1).

Predicted N-terminus: Glu 28

Request for sequence

蛋白结构(Molecular Characterization)

OSMR Structure

This protein carries a polyhistidine tag at the C-terminus

The protein has a calculated MW of 83.0 kDa. The protein migrates as 105-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

OSMR SDS-PAGE

Human OSMR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS

OSMR SEC-MALS

The purity of Human OSMR, His Tag (Cat. No. OSR-H52H9) is more than 85% and the molecular weight of this protein is around 105-125 kDa verified by SEC-MALS.

Report

 

背景(Background)

Oncostatin-M-specific receptor subunit beta(OSMRB) alos know as Interleukin-31 receptor subunit beta (IL-31RB), is an alternative subunit (OSMRβ) for an OSM receptor complex (a heterodimer of gp130 and OSMRβ), that is activated by OSM but not by LIF. OSMR beta associates with the low affinity OSM·gp130 complex to form a high affinity heterodimeric receptor that is capable of transducing OSM-specific signaling events.

 

前沿进展

 
 
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OSMR靶点信息
英文全称:Oncostatin-M-specific receptor subunit beta
中文全称:抑瘤素-M-特异性受体β亚基
种类:
上市药物数量:0详情
临床药物数量:1详情
最高研发阶段:临床二期
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