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Human GLP1R Protein, Fc Tag (MALS verified)

分子别名(Synonym)

GLP-1-R, GLP-1R, glucagon like peptide 1 receptor

表达区间及表达系统(Source)

Human GLP1R Protein, Fc Tag (GLR-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Glu 139 (Accession # P43220-1).

Predicted N-terminus: Ala 21

Request for sequence

蛋白结构(Molecular Characterization)

GLP1R Structure

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 40.2 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

GLP1R SDS-PAGE

Human GLP1R Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS

GLP1R SEC-MALS

The purity of Human GLP1R Protein, Fc Tag (Cat. No. GLR-H5253) is more than 85% and the molecular weight of this protein is around 90-115 kDa verified by SEC-MALS.

Report

 

活性(Bioactivity)-ELISA

GLP1R ELISA

Immobilized Human GLP1R Protein, Fc Tag (Cat. No. GLR-H5253) at 1 μg/mL (100 μL/well) can bind GLP-1R antibody with a linear range of 0.2-8 ng/mL (QC tested).

Protocol

 

背景(Background)

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke.

 

前沿进展

 
 
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GLP1R靶点信息
英文全称:Glucagon-like peptide-1
中文全称:胰高血糖素类肽-1
种类:
上市药物数量:0详情
临床药物数量:1详情
最高研发阶段:临床一期
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