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Canine CD3 epsilon Protein, His Tag (MALS verified)

分子别名(Synonym)

FLJ18683,T3E,TCRE,CD3E,CD3-epsilon

表达区间及表达系统(Source)

Canine CD3 epsilon Protein, His Tag (CDE-C52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Leu 122 (Accession # P27597).

Predicted N-terminus: Gln 22

蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 16.7 kDa. The protein migrates as 19-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

CD3 epsilon SDS-PAGE

Canine CD3 epsilon Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS

CD3 epsilon SEC-MALS

The purity of Canine CD3 epsilon Protein, His Tag (Cat. No. CDE-C52H3) is more than 90% and the molecular weight of this protein is around 32-45 kDa verified by SEC-MALS.

Report

 

背景(Background)

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

 

前沿进展

 
 
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CD3 epsilon靶点信息
英文全称:T-cell surface glycoprotein CD3 epsilon chain
中文全称:T细胞表面糖蛋白CD3ε链
种类:Homo sapiens
上市药物数量:3详情
临床药物数量:7详情
最高研发阶段:批准上市
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