膜杰作
Star Staining
描述/背景（Background）
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules 13. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration. Plays a role in enhancing learning and memory performance (By similarity).
种属（Host Species）
Rabbit
克隆号（Clone）
5A6
适用方法（Application）
IHC
效价（Property）
1：1000
状态（State）
Liquid
阳性对照（Positive Control）
Human placentaTissues
克隆类型（Clonality）
Monoclonal
分子别名（Synonym）
ERBB, ERBB1
研究领域（Research Field）
Cancer Drug Targets
抗体来源（Source）
Rabbit
同种型（Isotype）
IgG
储存（Storage）
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
典型数据（Typical Data）
质控样本（Control Sample）
Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelled with HGS-S264 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
肿瘤样本（Cancer Sample）
Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S264 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
