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 >  Protein>CLEC7A >CL7-H5248

Human CLEC7A Protein, His Tag

分子别名(Synonym)

BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2

表达区间及表达系统(Source)

Human CLEC7A Protein, His Tag (CL7-H5248) is expressed from human 293 cells (HEK293). It contains AA Thr 66 - Met 201 (Accession # NP_072092).

Request for sequence

蛋白结构(Molecular Characterization)

CLEC7A Structure

This protein carries a polyhistidine tag at the N-terminus

The protein has a calculated MW of 17.5 kDa. The protein migrates as 15-17 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

CLEC7A SDS-PAGE

Human CLEC7A Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

 

背景(Background)

Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684).
Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity).
Enhances cytokine production in macrophages and dendritic cells (By similarity).
Mediates production of reactive oxygen species in the cell (By similarity).
Mediates phagocytosis of C.albicans conidia (PubMed:17230442).
Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity).

 

前沿进展

 
 
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CLEC7A靶点信息
英文全称:C-type lectin domain family 7 member A
中文全称:C型凝集素域7家族成员A
种类:
上市药物数量:0详情
临床药物数量:1详情
最高研发阶段:临床阶段不明
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