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 >  Beads>uPAR >MBS-K076

Human uPAR-coupled Magnetic Beads

热销产品推荐:The Magnetic Stand (Cat.No. MB-01 & Cat.No. MB-02) can be used in conjunction with Beads.

ItemsSize (2mg)Size(2mg X 5)
Particle size2 μm2 μm
Physical appearancePowder mixturePowder mixture
Amount of Coupled Protein≈1371pmol(48μg) uPAR protein/mg beads≈1371pmol(48μg) uPAR protein/mg beads
Capacity>277pmol (20μg) Anti-uPAR Ab/mg beads>277pmol (20μg) Anti-uPAR Ab/mg beads
FormulationPBS, pH7.4,with 10% TrehalosePBS, pH7.4,with 10% Trehalose
Reconstitution2mL ultrapure water (1 mg beads/mL)2mL ultrapure water (1 mg beads/mL)

背景(Background)

Tumors are the result of uncontrolled proliferation of cells in different organs. Tumor development is a multistage process, that includes the generation of primary tumors, separation of tumors from primary sites, degradation of extracellular matrix (ECM), and distant metastasis of tumors. A variety of genes play important roles in the development of tumors, including the cell surface receptor urokinase-type plasminogen activator receptor (uPAR). uPAR is highly expressed in a variety of tumor cells, and a variety of signals regulated by uPAR play significant roles in tumor cell proliferation and metastasis, tumor-related glycolysis, the tumor microenvironment and angiogenesis. Studies have found that some specific drugs and antibodies have unique inhibitory effects on uPAR.

应用说明(Application)

This product is intended for immunocapture, biopanning and flow cytometry. This is a non-sterile product.

*The Isotype control (Cat. No. SMB-B01) is sold separately.

重构方法(Reconstitution)

See Certificate of Analysis (CoA) for detailed instruction.

存储(Storage)

Upon receipt, please store the Beads at -20°C. The shelf life is 1 year at -20 °C.

Please avoid more than 3 freeze-thaw cycles once reconstitution, immediate use after reconstitution is highly recommended.

制剂(Formulation)

Please contact us for detailed information.

Contact us for customized product form or formulation.

 

典型数据-Typical Data

uPAR TYPICAL DATA

Immobilized 48.8μg Biotinylated Human uPAR protein to 1mg Beads can bind the Anti-uPAR Antibody with an EC50 0.52 μg/mL (QC tested).

Protocol

 

前沿进展

 
 
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uPAR靶点信息
英文全称:Urokinase plasminogen activator surface receptor
中文全称:尿激酶型纤溶酶原激活物表面受体
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:5详情
最高研发阶段:临床二期
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