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 >  Protein>TGF-beta RI >TG1-H5254

Human TGF-beta RI Protein, Fc Tag (MALS verified)

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分子别名(Synonym)

TGFR-1, ALK-5, TGF-beta receptor type-1, Activin receptor-like kinase 5

表达区间及表达系统(Source)

Human TGF-beta RI Protein, Fc Tag (TG1-H5254) is expressed from human 293 cells (HEK293). It contains AA Leu 34 - Leu 126 (Accession # P36897-1).

Request for sequence

蛋白结构(Molecular Characterization)

TGF-beta RI Structure

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 36.7 kDa. The protein migrates as 43-48 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

TGF-beta RI SDS-PAGE

Human TGF-beta RI Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS

TGF-beta RI SEC-MALS

The purity of Human TGF-beta RI Protein, Fc Tag (Cat. No. TG1-H5254) is more than 85% and the molecular weight of this protein is around 75-90 kDa verified by SEC-MALS.

Report

 

活性(Bioactivity)-SPR

TGF-beta RI SPR

Human TGFB1, premium grade (Cat. No. TG1-H4212) immobilized on CM5 Chip can bind Human TGF-beta RI Protein, Fc Tag (Cat. No. TG1-H5254) with an affinity constant of 99.2 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

 

背景(Background)

TGF type I receptor also called the activin receptor-like kinase 5 (ALK5) and involved in TGF signaling. TGFβ signaling is mediated by the interaction of TGFβ ligands (TGFβ 1, 2 or 3) with cell surface receptors, the TGF type I, type II and type III receptors. Signaling is initiated by binding of TGF to the TGF type II receptor forming a ligand-receptor complex which interacts with the TGF type I receptor.

 

前沿进展

 
 
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TGF-beta RI靶点信息
英文全称:Transforming growth factor beta receptor 1
中文全称:转化生长因子β受体1
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:8详情
最高研发阶段:临床二期
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