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 >  Protein>Hemagglutinin (HA) >HA2-V52H9

Influenza A (A/Sydney/1304/2022) Hemagglutinin (HA) Protein, His Tag

分子别名(Synonym)

HA,Hemagglutinin

表达区间及表达系统(Source)

Influenza A (A/Sydney/1304/2022) Hemagglutinin (HA) Protein, His Tag (HA2-V52H9) is expressed from human 293 cells (HEK293). It contains AA Gln 17 - Asp 529 (Accession # EPI2304607, GISAID).

Predicted N-terminus: Gln 17

Request for sequence

蛋白结构(Molecular Characterization)

Hemagglutinin (HA) Structure

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 59.3 kDa. The protein migrates as 80-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Hemagglutinin (HA) SDS-PAGE

Influenza A (A/Sydney/1304/2022) Hemagglutinin (HA) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

 

背景(Background)

Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.

 

前沿进展

 
 
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Hemagglutinin (HA)靶点信息
英文全称:Influenza virus hemagglutinin glycoproteins
中文全称:血凝素
种类:Influenza A virus
上市药物数量:0详情
临床药物数量:1详情
最高研发阶段:临床一期
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